Effects of hyaluronic acid and chondroitin sulfate on acute radiation proctitis in rats

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dc.authorscopusid55169033600
dc.authorscopusid35622851900
dc.authorscopusid14623050100
dc.authorscopusid15128592000
dc.authorscopusid58284194800
dc.authorscopusid8901271400
dc.authorscopusid23028712700
dc.contributor.authorYoldas, Mehmet
dc.contributor.authorYoldas, Tayfun
dc.contributor.authorSolak, Ilhami
dc.contributor.authorCaliskan, Cemil
dc.contributor.authorCin, Samed
dc.contributor.authorDoganavsargil, Basak
dc.contributor.authorSezak, Murat
dc.date.accessioned2024-08-25T18:45:28Z
dc.date.available2024-08-25T18:45:28Z
dc.date.issued2023
dc.departmentEge Üniversitesien_US
dc.description.abstractBACKGROUND: This study was designed to investigate the prophylactic and therapeutic effects of hyaluronic acid and chondroitin sulfate combination (HA/CS) on a model of acute radiation proctitis.METHODS: Rats were divided into five groups: SHAM; irradiation (IR) + saline (1 mL for 5th and 10th day); IR + HA/CS (1 mL for 5th and 10th day). A single fraction of 17.5 Gy was delivered to each rat. HA/CS was administered rectally each day after irradiation. Each rat was observed daily for signs of proctitis. Irradiated rats were euthanized on days 5 and 10. The mucosal changes were evaluated macroscopically and pathologically.RESULTS: According to the clinical findings, five rats in the irradiation + saline group showed grade 3-4 symptoms on the 10th day. No significant difference in the macroscopic finding scores on the 5th day was observed between the irradiation + saline and irradiation + HA/CS groups. In the pathological examination, radiation-induced mucosal damage was the most prominent finding 10 days after irradiation in saline-treated rats. On the 10th day, the irradiation + HA/CS group showed mild inflammation and slight crypt changes, which corresponded to grade 1-2 pathological findings.CONCLUSION: We think that HA/CS used in radiation cystitis can be beneficial for radiation proctitis.en_US
dc.identifier.doi10.14744/tjtes.2023.61582
dc.identifier.endpage552en_US
dc.identifier.issn1306-696X
dc.identifier.issn1307-7945
dc.identifier.issue5en_US
dc.identifier.pmid37145048en_US
dc.identifier.scopus2-s2.0-85159922997en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage547en_US
dc.identifier.trdizinid1189530en_US
dc.identifier.urihttps://doi.org/10.14744/tjtes.2023.61582
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1189530
dc.identifier.urihttps://hdl.handle.net/11454/101580
dc.identifier.volume29en_US
dc.identifier.wosWOS:000988268000001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTurkish Assoc Trauma Emergency Surgeryen_US
dc.relation.ispartofUlusal Travma Ve Acil Cerrahi Dergisi-Turkish Journal of Trauma & Emergency Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240825_Gen_US
dc.subjectChondroitin sulfateen_US
dc.subjecthyaluronic aciden_US
dc.subjectradiation proctitisen_US
dc.subjectManagementen_US
dc.subjectDamageen_US
dc.subjectOilen_US
dc.titleEffects of hyaluronic acid and chondroitin sulfate on acute radiation proctitis in ratsen_US
dc.typeArticleen_US

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