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Öğe Sleep Quality in Patients with Ankylosing Spondylitis(Galenos Publ House, 2023) Cinar, Ece; Kerim, Duygu; Kirazli, YesimChronic pain and inflammation, loss of function, immobility and systemic involvement that are all characteristics of ankylosing spondylitis (AS) have been proposed to cause sleep problems. Almost 70-90% of patients with AS are reported to suffer from disturbed sleep. There are many indices that aim to assess quality and duration of sleep in clinical and academic settings. We have carried out a pilot study and enrolled 70 patients with AS and questioned each subject with a single question that assessed their quality of sleep. This question was taken from the 4th item of the Hamilton Anxiety scale and has been previously used in this population. We have asked patients to assess their sleep quality and score it from 0 to 4, 0 denoting no sleep disturbance and 4 denoting very severe sleep disturbance. The question was well understood and answered fast, causing no delay in routine patient care. Almost 90% of our patients reported some level of sleep disturbance. We have found a significant correlation between disease activity measured by Bath Ankylosing Spondylitis Disease Activity index and severity of sleep disturbance (p<0.05, r=0.34). Assessing quality of sleep in the routine clinical setting does not need to take a very long time and carries valuable information regarding patients' physical and mental wellbeing.Öğe Prevalence of Osteoporosis and Osteoporotic Vertebral Fractures in Turkish Patients with Ankylosing Spondylitis: A Retrospective Cross-sectional Study(Galenos Publ House, 2023) Cinar, Ece; Kirazli, Yesim; Kerim, Duygu; Karabulut, GoncaObjective: Ankylosing spondylitis (AS) is a chronic inflammatory disease mainly affecting the vertebral column that is the prototype of the spondyloarthritides and is characterized by bone marrow edema, osteitis, erosions, enthesopathy, new bone formations and sclerosis. A decrease in bone mineral density (BMD), in addition to later restrictions in movement and muscle weakness, predisposes the patient to osteoporotic fractures. In this retrospective study, we aimed to assess the prevalence of osteoporosis (OP) and osteoporotic vertebral fractures. Materials and Methods: This study was conducted in Ege University Faculty of Medicine, Departments of Physical Medicine and Rehabilitation and Rheumatology on patients who were diagnosed with AS and who had in the previous year received a BMD examination. Demographic and disease information, Bath Ankylosing Spondylitis Disease Activity index scores and if present, findings of vertebral radiographs and vitamin D levels were recorded from patient files. These parameters were used to compare patients with or without OP. Results: One hundred consecutive patients that were seen in our outpatient clinic and who met the inclusion criteria were enrolled in this study. In BMD examinations, 48% of subjects were found to have OP or osteopenia. Sixty radiographs were reached and 16% of subjects were found to have at least one vertebral fracture. We detected a significant difference between these groups regarding age, sex, disease duration and BMD and T-scores at the levels of femur neck and total hip (p<0.05). We did not detect a significant correlation between clinical parameters and parameters related to OP (p>0.05). Conclusion: The presence of concomitant OP in patients with AS is significant for increased fracture risk, also recurrent vertebral fractures may exacerbate the spinal deformities caused by the disease itself. It bears importance that clinicians be aware of increased risk of OP to be able to better manage pain and function loss in this patient population.Öğe Detection of differential item functioning with latent class analysis: PISA 2018 mathematical literacy test(Izzet Kara, 2024) Dascioglu, Selim; Ogretmen, TuncayThe purpose of this research is to determine whether PISA 2018 mathematical literacy test items show a differential item functioning across countries. For this purpose, only the items in booklet number three were examined using the MIMIC method with Latent Class Analysis (LCA) approach. PISA 2018 tests are mostly developed in English. Therefore, in DIF analyses, the reference group is the UK, while the focal groups consist of the other countries examined in the research (T & uuml;rkiye, Finland, Japan, and the USA). According to the results, of the 23 test items, statistically significant DIF was observed in eight items in the UK-T & uuml;rkiye sample, in seven items in the UK-Finland sample, in eleven items in the UK-Japan sample, and in three items in the UK-USA sample. It is seen that the effect and size of DIF in non-homogeneous groups differ between groups and these effects can be examined in more detail with the LCA method.Öğe A Childhood Inflammatory Myopathy with Cytochrome Oxidase Deficiency: Which Came First, the Chicken or the Egg?(Galenos Publ House, 2023) Diniz, Gulden; Yavascan, Onder; Sarkis, Umit Basak; Yildirim, Zubeyde; Alparslan, Caner; Ozturk, Can; Berdeli, AfigInflammatory myopathies are autoimmune disorders rarely seen in childhood. Normally high-dose corticosteroid is the current treatment for inflammatory myopathies. For a specific subgroup of patients with inflammatory myopathy with cytochrome oxidase (COX)-negative myofibers that do not typically respond to corticosteroid treatment, and methotrexate (MTX) is used for therapy. Herein we present a 10-year-old girl who initially received clinical diagnosis of juvenile inflammatory myopathy which did not respond to corticosteroid treatment. Examination of her muscle biopsy specimen showed the presence of COX-negative muscle fibers which are very rarely seen in childhood inflammatory myopathies, and she was diagnosed as inflammatory myopathy characterized with COX-negative myofibers. The patient, who recovered with MTX therapy underwent genetic examination 3 years after the treatment was terminated. The sequence analyses of mitochondrial DNA (mtDNA) identified 19 variants in the rRNA, ND2, ND4, ND5, COX1, COX3, and CytB genes of the mtDNA of the patient and her mother. These mutations generally induce the production of synonym amino acids. However, four missense mutations on the ND4, ATP6, and CytB genes have caused structural changes in amino acids. None of these mutations have been previously reported as pathogenic variants. We have thought that these variations in such essential genes might destabilize mtDNA and could probably affect the ATP synthesis in our patient. Our final diagnosis was established based on abnormal inflammatory response induced by a hereditary mtDNA defect in a child with mitochondrial myopathy, rather than an inflammatory myopathy with COX deficiency.Öğe Nutrition Education via A Mobile Application on Weight Loss and Quality of Life: A Randomized Controlled Trial(Marmara Univ, Inst Health Sciences, 2024) Peksever, Dona; Seckiner, Selda; Meseri, ReciObjective: To evaluate the effect of nutrition education supported by MOtiVE mobile application on weight loss and quality of life (QoL). Methods: In this pilot randomized-controlled study, 79 overweight/obese patients who presented to University Hospital between MarchSeptember 2018 to consult a dietitian, were included. All the participants were provided with a weight-loss diet program. Then, participants were randomized to experimental and control groups. During the first interview, all participants completed the questionnaire and anthropometric measurements were done. BMI, the scores obtained from different QoL scales, and Healthy Eating Index (HEI) were the dependent variables. Daily messages were sent to cases for 3 months via MOtiVE mobile application. All the participants were asked to be present three months later for a follow-up appointment. Using SPSS 25.0, change in BMI, QoL scores, and other variables within both groups were assessed via Wilcoxon signed-rank test and McNemar chi-square test. Results: 20 cases and 18 controls completed the study. The mean BMI decreased significantly in both groups being more predominant in cases (p=.001 for cases and p=.006 for controls). Waist circumference decreased (p=.029), self-esteem (p=.035) and healthy eating scores (p=.007) increased only in cases. Hence there were significant improvements in cases, in the final evaluation, there were no significant differences between the groups (p>.05) Conclusion: Nutrition education supported by MOtiVE mobile application improved anthropometric measurements, self-esteem, quality of life, and healthy eating habits of the overweight/obese participants. Free mobile applications can be used in increasing motivation to adopt new behaviors to tackle obesity.Öğe Cardiac Amyloidosis: Clinical Features, Pathogenesis, Diagnosis, and Treatment(Federation Turkish Pathology Soc, 2024) Argon, Asuman; Nart, Deniz; Barbet, Funda Y. I. L. M. A. Z.Cardiac amyloidosis is a type of amyloidosis that deserves special attention as organ involvement significantly worsens the prognosis. Cardiac amyloidosis can be grouped under three main headings: immunoglobulin light chain (AL) amyloidosis that is dependent on amyloidogenic monoclonal light chain production; hereditary Transthyretin (TTR) amyloidosis that results from accumulation of mutated TTR; and wild-type (non-hereditary) TTR amyloidosis formerly known as senile amyloidosis. Although all three types cause morbidity and mortality due to severe heart failure when untreated, they contain differences in their pathogenesis, clinical findings, and treatment. In this article, the clinical features, pathogenesis, diagnosis, and treatment methods of cardiac amyloidosis will be explained with an overview, and an awareness will be raised in the diagnosis of this disease.Öğe The Role of Hematological Parameters in Children with COVID-19, MIS- C, and Other Viral Infections(Galenos Publ House, 2023) Arslan, Sema Yildirim; Bal, Zumrut Sahbudak; Ozenen, Gizem Guner; Bilen, Nimet Melis; Ozkaya, Pinar Yazici; Ozkinay, Ferda; Karapinar, BulentObjective: It is known that coronavirus disease-2019 (COVID-19) showed a clinical course with milder symptoms in children than in adults. However, a multisystem inflammatory syndrome in children (MIS-C), which developed 2-4 weeks after COVID-19 infection, emerged in April 2021. Other respiratory viruses such as influenza, respiratory syncytial virus, and parainfluenza spread worldwide after loosening pandemic restrictions. Pediatricians were challenged to distinguish COVID-19, MIS-C, and other viral infections from each other. Herein, we have aimed to determine basic, simple hematological parameters that can predict the prognosis and outcomes of the patients with COVID-19 and MIS-C. Method: In this study, 300 pediatric inpatients including those with MIS-C, COVID-19, and other respiratory virus infections admitted to Ege University Faculty of Medicine between January 2018 and September 2021, were retrospectively evaluated. Results: The neutrophil-to-lymphocyte ratio (NLR), neutrophil- to-monocyte ratio (NMR), derived NLR, and the systemic inflammatory index were higher in the MIS- C patients compared to others. The lymphocyte-to-monocyte ratio (LMR) and platelet- to-lymphocyte ratio ( PLR) were lower in children with COVID- 19 disease than those with MIS-C (p<0.05). Conclusions: In this study, we have shown that commonly used hematological tests, especially higher values of NLR, NMR for children with MIS- C, and lower levels of LMR for children with COVID-19, are significant and can help to determine the possible disease course of children at an early stage.Öğe Critical evaluation of publications and patents in nanobiotechnology-based research in the last decade(Walter De Gruyter Gmbh, 2024) Ulucan-Karnak, Fulden; Kuru, Cansu Ilke; Sagin, Ferhan GirginNanobiotechnology is a specific field of biotechnology that utilizes nanoscale methods and materials to investigate biological systems and create innovative medical technologies. This review discusses the diverse use of nanobiotechnology in health, focusing on both its superior properties and challenges. The main aims of this report are to present and elaborate on the global market share of this growing field as well as the scientific output, regarding publications and patents in the last decade. Quantitative data is derived from the Statnano database, which includes information related to the articles from the Web of Science (WoS) and approved patents from the European Patent Office and the United States Patent and Trademark Office. The final aim of this review is to provide some suggestions based on these data. Government support is the most important driving force in building up research and publications. Support for advancement in nanotechnology to fabricate products for commercial and public benefit is the top priority of developed nations. Thus, entrepreneurial training of young researchers, and collaborations between scientists, policymakers, investors, and citizens, should be encouraged. To work together globally and set international standards for the creation of consistent methods in characterizing nanoscale products with biological systems is imperative.Öğe Does fear of activity predict exercise capacity in patients with coronary artery disease in both sexes? A cross-sectional multicenter study(Baycinar Medical Publ-Baycinar Tibbi Yayincilik, 2024) Demirsoy, Nesrin; Taskiran, Ozden Ozyemisci; Atan, Tugba; Durmus, Dilek; Tur, Birkan Sonel; Findikoglu, Gulin; Guzel, RenginObjectives: This study aimed to identify whether fear of activity predicts exercise capacity in patients with coronary artery disease (CAD) and whether there is a difference between sexes regarding this relationship. Patients and methods: One hundred ninety-seven patients (145 males, 52 females; mean age: 56.3 +/- 10.8 years; range, 22 to 80 years) with a diagnosis of CAD or cardiac event in the previous one to 60 months were enrolled in this cross-sectional multicenter study between November 2015 and February 2017. Demographic and clinical features were recorded. Fear of activity was assessed by the fear of activity scale in patients with CAD (FactCAD). A 6 -min walk test was used to assess exercise capacity. Results: Female participants were older, less educated, and less employed (p=0.045, p=0.048, and p<0.001, respectively) than males. Prevalence of myocardial infarction was higher in males. Comorbidities were higher in females. Multiple linear regression predicted 6 -min walk distance (6MWD) based on FactCAD, sex, and education level with an r -squared of 0.321 (p<0.001). Fear of activity had an effect on walking distance in males (each additional score of FactCAD predicts a decrease of 1.3 m in 6MWD), together with disease duration, presence of chronic pulmonary disease, and low back pain, whereas fear of activity was not a predicting factor on walking distance in females. Age, education, and presence of angina predicted 6MWD in females. Conclusion: This study emphasizes that fear of activity is one of the predictors of 6MWD in males with CAD, and its assessment is recommended as a possible barrier to rehabilitation.Öğe Effects of Functional Pinealectomy on Immunity, Hematopoietic, Gastrointestinal and Urinary Systems in Experimentally Malnutritioned Rats(Marmara Univ, Inst Health Sciences, 2024) Turgut, Yaar Bari; Sahin, Cem; Uyanikgil, Yigit; Yilmaz, Mustafa; Tomruk, Canberk; Gencer, Cevat; Cevik, OzgeObjective: The aim of this study was to demonstrate morphological changes in immunity, hematopoietic, gastrointestinal and urinary systems in different melatonin (MEL) release situations in a rat model of protein energy malnutrition (PEM). Method: A total of 32 adult male Wistar rats were assigned into four equal groups: normal control; PEM light/dark; PEM light, called functional pinealectomy (Px); and PEM dark. PEM was produced with a 50% restricted diet, Px was produced by keeping rats in continuous light environment for 24 hours, and complete blood count and serum albumin level were analyzed at the end of the 6-week experimental period. Measurements of weights of body and some visceral organs were obtained, biochemical and morphological parameters were analyzed in addition to measurements of malondialdehyde (MDA), total glutatione (GSH), tumor necrosis factor (TNF)-alpha and interleukin-10 (IL-10) in tissue samples. Results: A reduction in the weights of body and visceral organs of animals in the PEM groups was accompanied by hypoalbuminemia, anemia, leukopenia and lymphopenia, and higher MDA, GSH, TNF-alpha and IL-10 levels in visceral tissues. There was a significant decrease in parenchymal cells of the liver and spleen, duodenal villi, lymphoid structures and kidney glomeruli, but there was an increase in the spleen capsule thickness and renal Bowman's space, sinusoidal congestion and fat accumulation in the liver. Importantly, these findings were milder in the PEM dark group, while they were prominent in the PEM light group. Conclusion: This study suggests that MEL has a protective role in reducing the negative effects of PEM, making it a potential therapeutic agent for further investigation.Öğe The effects of different starch levels on the physical quality of high-oil extruded fish feed(Ege Univ, Fac Fisheries, 2024) Soker, Pinar Demir; Kop, Aysun; Korkut, Ali YildirimIn this study, the effects of different starch levels (5%, 8% and 11%) on the physical properties of extruded fish feeds with high oil content (22%) were investigated. For this purpose, 3 types of extruded trout feed with different starch levels (S5, S8 and S11) were produced. Physical (moisture, feed diameter, bulk density and pellet durability) and chemical (lipid, starch, water absorption index, water solubility index and water stability) analyses of these feeds were performed in 3 repetitions on the samples taken from the extruder outlet, lubrication outlet and sieve outlet. An increase in the amount of starch in the feed caused an increase in feed diameter and durability of the pellets, while a decrease in bulk density was observed. According to the results of the chemical analysis, it was seen that the increase in the starch ratio had no effect on the crude oil and water solubility index values, the best water absorption index value was in the S8 feed, and the water stability values decreased from S5 to S11.Öğe Breastfeeding After Breast Augmentation Surgery: A Scoping Review(Aves, 2024) Kazankaya, Figen; Paker, Selin Ahsun; Bozkurt, Ozlem DemirelThe aim of this scoping review was to provide a comprehensive overview of research in the literature on breastfeeding experiences of mothers undergoing breast augmentation surgery and the factors influencing this, and to identify gaps in the literature that could inform future design and evaluation. The study was conducted as a comprehensive review based on the approach of Arksey and O'Malley. After scans of relevant databases, such as Scholar, Information Sciences Institute, Science Direct, Ovid, PubMed, and Scientific Information Database, all data were collected, summarized, and given a narrative explanation. In the literature, the correlation between topics involving women's health and aesthetic breast surgery could not be clearly shown. When certain illnesses appeared, aesthetic surgery was blamed, and women who had undergone breast augmentation surgery were undecided about breastfeeding when they became mothers. It was determined in this study that the effects on breastfeeding success in women who have undergone breast augmentation surgery fall principally under three headings: surgery type, placement of implant material, and surgery complications. It is crucial to provide detailed information about the possible consequences of this surgery to women of reproductive age considering this surgery.Öğe The Beneficial Effect of Exercise and Vitamin D Supplementation on Comorbidities Associated with Systemic Lupus Erythematosus(Duzce Univ, Fac Medicine, 2024) Gokcek, Ozden Canbay; Ozkeskin, Mehmet; Baser, MirayObjective: Systemic lupus erythematosus (SLE) is a multisystem chronic autoimmune disease characterized by recurrent and relapsing attacks that may affect the locomotor system as well as the liver and kidneys. Vitamin D deficiency is thought to playAa role in the pathogenesis of SLE. ATherefore, the primary aim of this literature review is to determine the role of vitamin D deficiency on SLE symptoms. The secondary aim is to explain the benefits of exercise on SLE-related comorbidities. Methods: A comprehensive literature search on SLE symptoms, biochemistry, and pathophysiology was conducted via Google Scholar. The impact of exercise on comorbidities associated with SLE was examined. Results: The precise etiology of the disease remains elusive, although there is mounting evidence that vitamin D deficiency is associated with symptoms of SLE. In addition to pharmacological treatment for the involvement of the locomotor system in SLE patients, physiotherapy applications are also included. This review presents evidence of the positive effects of exercise on pain, fatigue, and sleep problems caused by disease-related or side effects of pharmacological applications used in the treatment of SLE patients. Conclusions: It is not possible to correct the symptoms of SLE associated with vitamin D deficiency by means of vitamin D supplementation alone. At this juncture, it is hypothesized that exercise may offer potential benefits in correcting vitamin D deficiency. AConsequently, exercise exerts a beneficial influence on the comorbidities associated with SLE. AFuture studies should be planned to establish an appropriate exercise prescription for SLE.Öğe Tularemia: What Happens if Treatment is Delayed?(Bilimsel Tip Yayinevi, 2024) Dirik, Sukru; Tol, Cansu; Tasbakan, Meltem; Pullukcu, HusnuTularemia is a zoonotic disease transmitted to humans through arthropod bites, direct contact with infected animals, or consumption of water and food contaminated with animal carcasses or waste. This disease presents with various clinical courses and is endemic in our country. Anamnesis has an important role in diagnosis. Patients presenting with tonsillopharyngitis may cause a delay in diagnosis. If the initiation of antibiotic therapy is delayed, the clinical course is directly affected and the complication rate increases significantly. In this article, we present a case initially diagnosed with streptococcal tonsillopharyngitis, who underwent treatment with multiple antibiotics. Due to the delayed initiation of appropriate antibiotic therapy, the treatment duration was prolonged, leading to the development of various complications.Öğe The eTIMSS and TIMSS Measurement Invariance Study: Multigroup Factor Analyses and Differential Item Functioning Analyses with the 2019 Cycle(Assoc Measurement & Evaluation Education & Psychology, 2024) Yalcinkaya, Murat; Atilgan, Hakan; Dascioglu, Selim; Aydin, BurakIn this study, measurement invariance and differential item functioning (DIF) studies of the TIMSS 2019 4th and 8thgrade mathematics and science achievement tests were conducted for the country groups participating in both TIMSS and eTIMSS. The study sample consisted of 9560 responders of the first booklet of the 2019 cycle. Multiple Group Confirmatory Factor Analysis (MGCFA) was utilized to test measurement invariance, and Mantel-Haenszel (MH), Logistic Regression (LR), and SIBTEST were used for the DIF analyses. The measurement invariance results indicated strict invariance between groups for all tests which included 111 items in total. In the DIF analyses, for the 4th and 8th -grade mathematics tests, only three items showed moderate DIF with MH, and four items showed DIF with SIBTEST. For the 4th -grade science test, one item showed moderate DIF with both MH and SIBTEST. However, in the 8th -grade science test, no items showed DIF with MH and LR methods, while four items showed moderate DIF with SIBTEST. Overall, MH and SIBTEST techniques were in agreement, whereas LR method produced inconsistent results and showed disagreement with these two methods. The results of the measurement invariance analysis and the LR method were consistent and indicated equivalency of TIMSS and e-TIMSS scores.Öğe The Predictors of COVID-19 Immunogenicity Elicited by Vaccines Against SARS-CoV-2 in Stem Cell Transplant Recipients(Bilimsel Tip Yayinevi, 2024) Elbahr, Umran; Erdem, Hakan; Ankarali, Handan; Reyes, Clark Steven Delos; Pastrana, Jennie; Vineeth, Chithra; Hejres, SuhaIntroduction: The literature falls short in providing thorough investigations into the influence of COVID-19 vaccination among those undergoing hematopoietic stem cell transplantation (HSCT). Materials and Methods: This prospective study evaluates COVID-19 antibody levels in HSCT recipients. The HSCT patients, having undergone transplantation at least three months prior, received BNT162b2 mRNA, Gam-COVID-Vac adenoviral, or BBIBP-CorV inactivated vaccines. Blood samples were taken 2-24 weeks post second dose. Results: The study involved 28 participants, comprising nine allogeneic-HSCT and 19 autologous-HSCT recipients. Among them, 18 (64.2%) exhibited positive results in SARS-CoV-2 neutralizing antibody tests, occurring at a median of 10.5 weeks (ranging from 2 to 24 weeks). In multivariate logistic regression analysis, age and a higher Charlson Comorbidity Index emerged as statistically significant variables linked with suboptimal antibody responses. Interestingly, no significant disparities surfaced in terms of anti-SARSCoV-2 spike, SARS-CoV-2 (IgG + neutralizing) antibodies, and SARS-CoV-2 (neutralizing) antibodies titers across various vaccine types and transplantation modes. However, the anti-SARS-CoV-2 nucleocapsid titers demonstrated a significant increase in patients who received the BBIBP-CorV inactivated vaccine (Sinopharm, China). Moreover, within the non -vaccinated BMT subgroup, a slightly higher yet insignificant incidence of COVID-19 was observed in comparison to the vaccinated subgroup (2/28-7.1% vs. 3/11-27.2%, p= 0.125). During the six-month post -vaccination follow-up, COVID-19 incidence was 144.9 per 1000 patient -years in the vaccinated group, contrasting with 545.4 per 1000 patient -years in the unvaccinated group. Hence, a substantial vaccination efficacy of 73.4% was noted. No fatalities were reported among either vaccinated or unvaccinated HSCT patients who contracted COVID-19 during the 30 -day follow-up period. Conclusion: The inactivated vaccine demonstrated antibody responses comparable to the Pfizer-BioNTech vaccine.Öğe Exploring the Association between Calling and Work Engagement: The Mediating Role of Psychological Needs Satisfaction and Perception of Meaningful Work (vol 43, pg 345, 2023)(Istanbul Univ, Fac Letters, Dept Psychology, 2024) Ersoy, Nevra Cem; Peker, Mehmet; Giray, Muazzez Deniz[Abstarct Not Available]Öğe Impact of surgery simulation using a 3-dimensional printed model on outcomes of hallux valgus surgery with distal chevron osteotomy: A randomized controlled trial(Turkish Assoc Orthopaedics Traumatology, 2024) Suer, Onur; Ozer, Mehmet Asim; Govsa, Figen; Ozturk, Anil Murat; Aktuglu, Salih KemalObjective: This study aimed to compare the outcomes of traditional surgery (TS) with those of a 3-dimensional model-assisted surgery (3DS) in hallux valgus (HV) surgery with distal chevron osteotomy. Methods: This randomized controlled trial study included 30 patients randomly grouped as TS and 3DS. In the 3DS group, the surgery was simulated on the 3D model before surgery, and that simulation was used as a guide during surgery. Various parameters, such as angles of the HV, intermetatarsal (IM), and distal metatarsal articular, were measured pre-surgery and during the final follow-up. The extent of lateralization of the first metatarsal (FM) head and plantar displacement of the FM head were assessed. Metrics like the duration of the osteotomy + lateralization + K wire fixation, tourniquet time, and fluoroscopy usage were recorded. All assessments were conducted inde-pendently and blindly. Patients remained unaware of their group allocation and the randomization procedure. Results: Both groups showed no statistical differences in gender, operated side, age, or follow-up duration. For instance, in the 3DS group (n = 15, age: 44.6 +/- 9.6 years, male/female: 14/1, side right/left: 11/4, follow-up duration: 29.4 +/- 8.7 months) and TS group (n = 15, age: 44.8 +/- 9.6 years, male/female: 13/2, side right/left: 10/5, follow-up duration: 28.8 +/- 8.4 months). The 3DS group, however, showed better metrics with osteotomy + lateralization + K wire fixation, tourniquet duration, and number of fluoroscopies at 12.4 +/- 1.2 minutes, 41.5 +/- 3.8 min-utes, 2.5 +/- 0.6 times. In contrast, the TS group recorded 17.1 +/- 1.5 minutes, 50.8 +/- 3.4 minutes, and 3.3 +/- 0.8 times, respectively (P < .001 for all). The 3DS group also achieved a more significant restoration of the IM angle (P < .001). Postsurgery, the 3DS group demonstrated superior outcomes in FM head lateralization, FM shortening, and plantar displacement (P < .001, P < .001 and P = .006, respectively, for all metrics). Only 1 patient in the 3DS group experienced a pin-tract infection, which was treated with wound care and oral antibiotics. Conclusion: Simulating surgery on a 3D model and using it as a guide significantly enhances surgical outcomes. Benefits include reduced operation time, tourniquet duration, decreased fluoroscopy usage, and improved first-ray alignment. The 3DS method also ensures better lateralization of the first metatarsal head and correction of the IM. Although 3D model-assisted HV chevron osteotomy surgery provides ideal deformity correction, it does not significantly affect postoperative functional outcomes.Öğe Subdural Empyema Caused by Brucellosis: A Case Report and Review of the Literature(Galenos Publ House, 2024) Akbulut, Bilal Bahadir; Erol, Anil; Boluk, Mustafa Serdar; Yurtseven, Taskin; Eraslan, Cenk; Arda, Bilgin; Biceroglu, HuseyinNeurobrucellosis is a rare and challenging complication of brucellosis. Its non-specific clinical presentation makes it challenging to diagnose. The coexistence of neurobrucellosis with subdural empyema is extremely rare, with only a few cases reported in the literature. Herein, we present the case of a 27-year-old male with a ventriculoperitoneal shunt in-situ and a history of exposure to Brucella via animal care and consumption of raw milk. The patient presented with a left frontal headache and vertigo following a head trauma. The initial cranial imaging demonstrated a left-sided subdural hematoma and slit ventricles. The patient underwent drainage by craniotomy. Brucella spp. was detected in the drained sample, and the patient was treated with a multi-modal approach, which included antibiotics and surgical drainage. The follow-up plan involved a repeat cranial computed tomography and shunt adjustment for recurrent subdural effusions. This case adds to the few reports of neurobrucellosis associated with subdural empyema. Furthermore, it highlights the importance of considering neurobrucellosis in patients with neurological symptoms and a subdural collection in brucellosis-endemic areas.Öğe Effects of lercanidipine on traumatic spinal cord injury: an experimental study(Turkish Assoc Trauma Emergency Surgery, 2024) Turk, Caglar; Bahadir, Sinan; Camlar, Mahmut; Gurel, Cevik; Buhur, Aylin; Kuscu, Gokce CerenBACKGROUND: Spinal cord injury is a devastating trauma that leaves survivors at risk for several medical complications throughout their lives. Lercanidipine, a third-generation calcium channel blocker, possesses anti-apoptotic, anti-inflammatory, and antioxidative properties. This study aimed to evaluate the neuroprotective effects of lercanidipine in an experimental spinal cord trauma model. METHODS: Twenty-one Wistar rats were randomly assigned to three groups. Group 1 (G1) underwent laminectomy. Group 2 (G2) were subjected to trauma following laminectomy. Group 3 (G3) were exposed to trauma following laminectomy and treated with lercanidipine. Lercanidipine was administered intraperitoneally for seven days. Histopathological and immunohistochemical evaluations were conducted. RESULTS: Regarding Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining, there was no significant difference among the groups. However, nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappa B) levels were significantly different across the groups. G2 had significantly higher NF-kappa B levels compared to G1 and G3. CONCLUSION: Lercanidipine, a third-generation calcium channel blocker, is effective against inflammatory responses induced in spinal cord injury. Further studies are required to determine its capability in preventing apoptosis or improving functional recovery. To the best of our knowledge, this study is the first in the literature to examine the neuroprotective effects of lercanidipine on spinal cord injury.