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Öğe Biomimetic approaches to the design of smart textiles(Elsevier, 2024) Namli E.M.; Sendemir A.Biomimetic technology offers a potential opportunity by establishing a link between natural materials and textiles. When the surfaces of plants, insects, and microorganisms in nature are examined, owing to their advantages such as complex, hierarchical microstructures, hydrophobic properties, and modifications by adapting to the environmental conditions, it is appealing to give textile products a more functional and sustainable structure inspired by these natural material surfaces. Adaptation of these structures into textiles leads to “smart” properties that can perceive and/or respond to environmental stimuli, without compromising comfort and durability. In this section, the use, integration, and future perspectives of the biomimetic approach with smart textile products from natural sources are examined. In addition, smart biomimetic materials used for textile engineering are summarized, and the design parameters, such as breathability, ultraviolet protection, sensing, self-cleaning, antifouling, and personalized health care, are focused on, and future prospects are discussed. © 2024 Elsevier Ltd. All rights reserved.Öğe Bioreactors in tissue engineering: mimicking the microenvironment(Elsevier, 2020) Bayir E.; Sahinler M.; Celtikoglu M.M.; Sendemir A.; Sendemir A.One of the main challenges that have kept tissue-engineered constructs from being widely adopted to clinics is poor cell survival due to limited mass transfer of oxygen and nutrients in thick, clinically relevant sizes of constructs. Tissue engineering bioreactors have been developed to overcome this mass transfer problem, introducing convection as well as diffusion in three-dimensional culture systems. They also provide highly controlled microenvironments for viability, repeatability, and standardization. This microenvironment can mimic the physiological niche, so that functional tissue maturation can be achieved. In this chapter the properties of different types of bioreactors that are commonly used for tissue engineering (TE) applications are examined. This chapter summarizes the main types of bioreactors used for TE, focusing on their design parameters and comparing their main prominences for particular applications. © 2020 Elsevier Ltd. All rights reserved.Öğe Dynamic models for investigating structure/function of biomaterials(Elsevier, 2023) Morcimen Z.G.; Gulicli B.; Sendemir A.The induction of regeneration in the musculoskeletal system with tissue-engineered grafts has been seen as a promising solution to the problems associated with autografts and allografts. Tissue engineering has the potential to develop the needed musculoskeletal tissue from the patient's own cells on 3D scaffolds. However, due to their load bearing characteristics and high mechanical demands associated with them in their physiological settings, successful and reproducible development of musculoskeletal tissues in vitro and their controllable functionality depend on optimizing appropriate mechanical microenvironment, as well as the biochemical factors, during in vitro culture time. Bioreactors provide dynamic mixing of the culture medium by convection, creating a controlled mass transfer. Controlling the mass transfer enables the cells in the tissue-engineered constructs to reach their nutrient and oxygen needs more easily in a 3D structure. In addition, the flow dynamics provided by bioreactors mimic the interstitial flow between blood and lymphatic vessels in musculoskeletal tissues. Furthermore, other external mechanical stimuli imposed by the correct design of bioreactors simulate the stresses the musculoskeletal tissues are exposed to during their physiological functions. Mechanical stimulation is crucial for the governance of mechanotransduction pathways that regulate the relevant cell behavior. In this chapter, musculoskeletal system tissue engineering examples performed in different types of bioreactors and the physical basis of the bioreactor design are discussed with examples, with special emphasis on stress type versus cellular behavior approach. © 2024 Elsevier Inc. All rights reserved.Öğe Investigation of the adherence and proliferation characteristics of SH-SY5Y neuron model cells on graphene foam surfaces(Elsevier Ltd, 2020) Morçimen Z.G.; Tasdemir S.; Erdem Ç.; Günes F.; Sendemir A.Graphene is a promising material for production of biocompatible surfaces with suitable physicochemical properties for effective adhesion, proliferation and differentiation of nerve cells. In this study, 3-dimensional (3D) graphene foam was synthesized via chemical vapour deposition method, and it was aimed to observe the effects of graphene foam scaffolds on SH-SY5Y dopaminergic neuron model cells before applying to clinics. Raman spectroscopy, XRD and SEM analyses were performed to characterize the graphene foam. Viability of SH-SY5Y cells cultured on graphene foam scaffolds was analysed on days 1, 4 and 7 by MTT. Furthermore, cell morphology was determined by fluorescence staining of the actin cytoskeleton. © 2019 Elsevier Ltd. All rights reserved.Öğe Prolonged electrical stimulation of neuronal PC12 cells using a microchip [PC12 sinir hücrelerinin mikroçip üzerinde uzun süreli elektriksel stimülasyonu](Institute of Electrical and Electronics Engineers Inc., 2019) Seven F.; Golcez T.; Sahinler M.; Sendemir A.; Karaman O.; Sen M.PC12 cell line is widely used to study neuronal differentiation behavior. This cell line differentiates in the presence of nerve growth factor (NGF), resulting in protrusions called neurites, dentrites and axons. Non-invasive electrical stimulation is known to have potential for use in the control of the activity and regeneration of neuron cells. In this study, the effects of longterm electrical stimulation on the behavior of PC12 cells and their differentiation in the presence of NGF were investigated using a microchip. Electrical stimulation was performed 2 hours a day for 2 days and all day (24 hours) and the results were compared to the condition in which no electrical stimulation was applied. The results clearly showed that the cells migrated towards the electrodes and the neurite orientation was promoted due to the electrical stimulation applied. However, the protrusion per cell decreased. The findings are thought to be useful in elucidating the effects of external electrical stimulation on neuron cell. © 2019 IEEE.
