Dynamic models for investigating structure/function of biomaterials
Küçük Resim Yok
Tarih
2023
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The induction of regeneration in the musculoskeletal system with tissue-engineered grafts has been seen as a promising solution to the problems associated with autografts and allografts. Tissue engineering has the potential to develop the needed musculoskeletal tissue from the patient's own cells on 3D scaffolds. However, due to their load bearing characteristics and high mechanical demands associated with them in their physiological settings, successful and reproducible development of musculoskeletal tissues in vitro and their controllable functionality depend on optimizing appropriate mechanical microenvironment, as well as the biochemical factors, during in vitro culture time. Bioreactors provide dynamic mixing of the culture medium by convection, creating a controlled mass transfer. Controlling the mass transfer enables the cells in the tissue-engineered constructs to reach their nutrient and oxygen needs more easily in a 3D structure. In addition, the flow dynamics provided by bioreactors mimic the interstitial flow between blood and lymphatic vessels in musculoskeletal tissues. Furthermore, other external mechanical stimuli imposed by the correct design of bioreactors simulate the stresses the musculoskeletal tissues are exposed to during their physiological functions. Mechanical stimulation is crucial for the governance of mechanotransduction pathways that regulate the relevant cell behavior. In this chapter, musculoskeletal system tissue engineering examples performed in different types of bioreactors and the physical basis of the bioreactor design are discussed with examples, with special emphasis on stress type versus cellular behavior approach. © 2024 Elsevier Inc. All rights reserved.
Açıklama
Anahtar Kelimeler
Bioreactors, Bone, Ligament, Mechanotransduction, Musculoskeletal system, Skeletal muscle, Tendon, Tissue engineering
Kaynak
Multiscale Cell-Biomaterials Interplay in Musculoskeletal Tissue Engineering and Regenerative Medicine
WoS Q Değeri
Scopus Q Değeri
N/A
