Prolonged electrical stimulation of neuronal PC12 cells using a microchip [PC12 sinir hücrelerinin mikroçip üzerinde uzun süreli elektriksel stimülasyonu]
Küçük Resim Yok
Tarih
2019
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Institute of Electrical and Electronics Engineers Inc.
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
PC12 cell line is widely used to study neuronal differentiation behavior. This cell line differentiates in the presence of nerve growth factor (NGF), resulting in protrusions called neurites, dentrites and axons. Non-invasive electrical stimulation is known to have potential for use in the control of the activity and regeneration of neuron cells. In this study, the effects of longterm electrical stimulation on the behavior of PC12 cells and their differentiation in the presence of NGF were investigated using a microchip. Electrical stimulation was performed 2 hours a day for 2 days and all day (24 hours) and the results were compared to the condition in which no electrical stimulation was applied. The results clearly showed that the cells migrated towards the electrodes and the neurite orientation was promoted due to the electrical stimulation applied. However, the protrusion per cell decreased. The findings are thought to be useful in elucidating the effects of external electrical stimulation on neuron cell. © 2019 IEEE.
Açıklama
2019 Medical Technologies Congress, TIPTEKNO 2019 -- 3 October 2019 through 5 October 2019 -- -- 154293
Anahtar Kelimeler
Electrical stimulation, Microchip, Neural differentiation, PC12 cells
Kaynak
TIPTEKNO 2019 - Tip Teknolojileri Kongresi
WoS Q Değeri
Scopus Q Değeri
N/A
