Anti-inflammatory and antioxidant properties of betaine protect against sepsis-induced acute lung injury: CT and histological evidence

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dc.authorscopusid57813869000
dc.authorscopusid57222041711
dc.authorscopusid55672440000
dc.authorscopusid57189713929
dc.authorscopusid6506580350
dc.authorscopusid55469991100
dc.contributor.authorSorgun, O.
dc.contributor.authorÇakır, A.
dc.contributor.authorBora, E.S.
dc.contributor.authorErdoğan, M.A.
dc.contributor.authorUyanıkgil, Y.
dc.contributor.authorErbas, O.
dc.date.accessioned2024-08-25T18:32:18Z
dc.date.available2024-08-25T18:32:18Z
dc.date.issued2023
dc.departmentEge Üniversitesien_US
dc.description.abstractThe aim of this research was to determine the anti-inflammatory effect of betaine on sepsis-induced acute respiratory distress syndrome (ARDS) in rats through histopathological examination, radiologic imaging, and biochemical analysis. Eight rats were included in the control group, and no procedure was performed. Feces intraperitoneal procedure (FIP) was performed on 24 rats to create a sepsis-induced ARDS model. These rats were separated into three groups as follows: FIP alone (sepsis group, n=8), FIP + saline (1 mL/kg, placebo group, n=8), and FIP + betaine (500 mg/kg, n=8). Computed tomography (CT) was performed after FIP, and the Hounsfield units (HU) value of the lungs was measured. The plasma levels of tumor necrosis factor (TNF)-a, interleukin-1b (IL-1b), IL-6, C-reactive protein, malondialdehyde (MDA), and lactic acid (LA) were determined, and arterial oxygen pressure (PaO2) and arterial CO2 pressure (PaCO2) were measured from an arterial blood sample. Histopathology was used to evaluate lung damage. This study completed all histopathological and biochemical evaluations in 3 months. All evaluated biomarkers were decreased in the FIP + betaine group compared to FIP + saline and FIP alone (all P<0.05). Also, the parenchymal density of the rat lung on CT and histopathological scores were increased in FIP + saline and FIP alone compared to control and these findings were reversed by betaine treatment (all P<0.05). Our study demonstrated that betaine suppressed the inflammation and ameliorated acute lung injury in a rat model of sepsis. © 2023, Associacao Brasileira de Divulgacao Cientifica. All rights reserved.en_US
dc.identifier.doi10.1590/1414-431X2023e12906
dc.identifier.issn0100-879X
dc.identifier.pmid37970921en_US
dc.identifier.scopus2-s2.0-85176919869en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1590/1414-431X2023e12906
dc.identifier.urihttps://hdl.handle.net/11454/100198
dc.identifier.volume56en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAssociacao Brasileira de Divulgacao Cientificaen_US
dc.relation.ispartofBrazilian Journal of Medical and Biological Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240825_Gen_US
dc.subjectAcute lung injuryen_US
dc.subjectBetaineen_US
dc.subjectRat modelen_US
dc.subjectSepsisen_US
dc.subjectbetaineen_US
dc.subjectC reactive proteinen_US
dc.subjectinterleukin 1betaen_US
dc.subjectinterleukin 6en_US
dc.subjectlactic aciden_US
dc.subjectmalonaldehydeen_US
dc.subjecttumor necrosis factoren_US
dc.subjectantiinflammatory agenten_US
dc.subjectantioxidanten_US
dc.subjectbetaineen_US
dc.subjecttumor necrosis factoren_US
dc.subjectanimal experimenten_US
dc.subjectanimal modelen_US
dc.subjectanimal tissueen_US
dc.subjectantiinflammatory activityen_US
dc.subjectantioxidant activityen_US
dc.subjectarterial carbon dioxide tensionen_US
dc.subjectarterial oxygen tensionen_US
dc.subjectArticleen_US
dc.subjectbiochemistryen_US
dc.subjectblood samplingen_US
dc.subjectcardiac punctureen_US
dc.subjectcomputer assisted tomographyen_US
dc.subjectcontrolled studyen_US
dc.subjectenzyme linked immunosorbent assayen_US
dc.subjecthistopathologyen_US
dc.subjectimmunohistochemistryen_US
dc.subjectlung injuryen_US
dc.subjectnonhumanen_US
dc.subjectraten_US
dc.subjectsepsis-induced acute lung injuryen_US
dc.subjectacute lung injuryen_US
dc.subjectanimalen_US
dc.subjectcomplicationen_US
dc.subjectlungen_US
dc.subjectlung injuryen_US
dc.subjectpathologyen_US
dc.subjectrespiratory distress syndromeen_US
dc.subjectsepsisen_US
dc.subjectSprague Dawley raten_US
dc.subjectx-ray computed tomographyen_US
dc.subjectAcute Lung Injuryen_US
dc.subjectAnimalsen_US
dc.subjectAnti-Inflammatory Agentsen_US
dc.subjectAntioxidantsen_US
dc.subjectBetaineen_US
dc.subjectLungen_US
dc.subjectLung Injuryen_US
dc.subjectRatsen_US
dc.subjectRats, Sprague-Dawleyen_US
dc.subjectRespiratory Distress Syndromeen_US
dc.subjectSepsisen_US
dc.subjectTomography, X-Ray Computeden_US
dc.subjectTumor Necrosis Factor-alphaen_US
dc.titleAnti-inflammatory and antioxidant properties of betaine protect against sepsis-induced acute lung injury: CT and histological evidenceen_US
dc.typeArticleen_US

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