Naloxone binding in the frontal cortex of postmortem human brain

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dc.contributor.authorPögün S.
dc.contributor.authorDemirgören S.
dc.contributor.authorKutay F.Z.
dc.contributor.authorHariri N.I.
dc.contributor.authorKaraali H.
dc.date.accessioned2019-10-27T00:35:21Z
dc.date.available2019-10-27T00:35:21Z
dc.date.issued1989
dc.departmentEge Üniversitesien_US
dc.description.abstract1. The binding of 3H-Naloxone to opiate receptors was characterized in the frontal cortex of human post-mortem brain samples and age related changes in opiate receptors were investigated. 2. Our study revealed the presence of two binding sites with different affinities for naloxone. 3. With increasing age, the opiate receptors tend to show greater affinity for the agonistic conformation; this may imply a decline in endogenous opioid peptides with age. © 1989.en_US
dc.description.sponsorship025/84en_US
dc.description.sponsorshipThis study was supported by the Ege University Research Foundation Grant No: 025/84. --en_US
dc.identifier.doi10.1016/0278-5846(89)90014-6en_US
dc.identifier.endpage171en_US
dc.identifier.issn0278-5846
dc.identifier.issue01.Feben_US
dc.identifier.pmid2546178en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage167en_US
dc.identifier.urihttps://doi.org/10.1016/0278-5846(89)90014-6
dc.identifier.urihttps://hdl.handle.net/11454/24391
dc.identifier.volume13en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofProgress in Neuropsychopharmacology and Biological Psychiatryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAgingen_US
dc.subjectnaloxoneen_US
dc.subjectopiate receptoren_US
dc.subjectpost-mortem human brainen_US
dc.titleNaloxone binding in the frontal cortex of postmortem human brainen_US
dc.typeArticleen_US

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