An examination of carbopol hydrogel/organogel bigels of thymoquinone prepared by microwave irradiation method

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dc.contributor.authorYapar, Evren Algin
dc.contributor.authorTanriverdi, Sakine Tuncay
dc.contributor.authorTural, Gulsen Aybar
dc.contributor.authorGumus, Zinar Pinar
dc.contributor.authorTurunc, Ezgi
dc.contributor.authorGokce, Evren Homan
dc.date.accessioned2020-12-01T11:58:04Z
dc.date.available2020-12-01T11:58:04Z
dc.date.issued2020
dc.departmentEge Üniversitesien_US
dc.description.abstractNigella sativa L. is shown wide spread over the world and contains many useful phytochemicals. Much of the biological activity of the seeds has been shown due to the presence of thymoquinone (TQ). Its poor aqueous solubility of TQ hinders its delivery to target site. the aim of this work was to prepare TQ bigels composed of Carbopol 974 P NF (C974) in PEG 400 (organogel) or C974 in water (hydrogel) with microwave heating method. A novel technique, high speed homogenization followed by microwave heating, was used to prepare organogels. the pH, electrical conductivity, differential scanning calorimetry, rheological properties, and morphological structure of the formulations have been evaluated, and the effect of microwave on drug content and TQ antioxidant activity has been investigated. the bigels of TQ were successfully producedviahigh-speed homogenization followed by microwave-assisted heating for the first time in this study. Highly lipophilic TQ was successfully dissolved in organogel, and it was not affected from the microwaves. It can be stated that microwave heating is a promising method to obtain C974 organogels and thus bigels with appropriate above indicated investigated physicochemical characteristics. the time and energy consumption could be decreased with microwave-assisted heating, especially for gel preparation in the field of pharmaceuticals.en_US
dc.identifier.doi10.1080/03639045.2020.1820031en_US
dc.identifier.endpage1646en_US
dc.identifier.issn0363-9045
dc.identifier.issn1520-5762
dc.identifier.issue10en_US
dc.identifier.pmid32935592en_US
dc.identifier.scopus2-s2.0-85091027825en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1639en_US
dc.identifier.urihttps://doi.org/10.1080/03639045.2020.1820031
dc.identifier.urihttps://hdl.handle.net/11454/61919
dc.identifier.volume46en_US
dc.identifier.wosWOS:000571605600001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofDrug Development and Industrial Pharmacyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNigella sativa Len_US
dc.subjectthymoquinoneen_US
dc.subjectgelen_US
dc.subjectmicrowave-assisted heating methoden_US
dc.subjectantioxidanten_US
dc.titleAn examination of carbopol hydrogel/organogel bigels of thymoquinone prepared by microwave irradiation methoden_US
dc.typeArticleen_US

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