An examination of carbopol hydrogel/organogel bigels of thymoquinone prepared by microwave irradiation method
Küçük Resim Yok
Tarih
2020
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Taylor & Francis Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Nigella sativa L. is shown wide spread over the world and contains many useful phytochemicals. Much of the biological activity of the seeds has been shown due to the presence of thymoquinone (TQ). Its poor aqueous solubility of TQ hinders its delivery to target site. the aim of this work was to prepare TQ bigels composed of Carbopol 974 P NF (C974) in PEG 400 (organogel) or C974 in water (hydrogel) with microwave heating method. A novel technique, high speed homogenization followed by microwave heating, was used to prepare organogels. the pH, electrical conductivity, differential scanning calorimetry, rheological properties, and morphological structure of the formulations have been evaluated, and the effect of microwave on drug content and TQ antioxidant activity has been investigated. the bigels of TQ were successfully producedviahigh-speed homogenization followed by microwave-assisted heating for the first time in this study. Highly lipophilic TQ was successfully dissolved in organogel, and it was not affected from the microwaves. It can be stated that microwave heating is a promising method to obtain C974 organogels and thus bigels with appropriate above indicated investigated physicochemical characteristics. the time and energy consumption could be decreased with microwave-assisted heating, especially for gel preparation in the field of pharmaceuticals.
Açıklama
Anahtar Kelimeler
Nigella sativa L, thymoquinone, gel, microwave-assisted heating method, antioxidant
Kaynak
Drug Development and Industrial Pharmacy
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
46
Sayı
10
