Analysis of blood gas beyond bicarbonate in outpatients with stage 3–5 chronic kidney disease

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dc.contributor.authorAktar, Merve
dc.contributor.authorYıldırım, Gizem
dc.contributor.authorDoğan, Ali Nazmi Can
dc.contributor.authorSerel, Ali
dc.contributor.authorTatar, Erhan
dc.contributor.authorBozacı, İlter
dc.contributor.authorMahşer, Alev
dc.date.accessioned2023-01-12T20:27:20Z
dc.date.available2023-01-12T20:27:20Z
dc.date.issued2020
dc.departmentN/A/Departmenten_US
dc.description.abstractObjectives: Metabolic acidosis is a common disorder seenin course of chronic kidney disease (CKD). In this study, weaimed to investigate the association of Base excess (BE),Anion gap (AG) and Delta Ratio with progression of CKD,renal replacement therapy (RRT) requirement and mortalityin patients with stage 3–5 CKD.Methods: A total of 212 patients with stage 3–5 CKD wereincluded in this study. Patients were divided into twogroups according to the baseline BE level. Patients werealso grouped according to the delta ratio such as non- AG,High AG and mixed type.Results: Mean BE level was significantly lower (?4.7 ± 4.0vs. ?3.3 ± 4.3; p=0.02) in patientswith CKD progression. Thepatients in group 1 (n: 130) (Be<?2.5) revealed more CKDprogression (%53 vs. %32; p=0.002), and RRT requirement(%35 vs.%15; p=0.001). Baseline BE <?2.5 (odds ratio, 0.38;95% CI, 0.16 to 0.91; p<0.05) and baseline GFR (odds ratio,0.94; 95% CI, 0.90 to 0.97; p<0.001) were independentlyrelated to RRT requirement. Delta BE was independentlyassociated with mortality (odds ratio, 0.90; 95% CI, 0.85–0.96; p<0.01).Conclusions: Low BE levels were associated with CKDprogression and RRT requirement. BE change is associatedwith mortality during the follow-up of thosepatients.en_US
dc.identifier.doi10.1515/tjb-2020-0073
dc.identifier.endpage898en_US
dc.identifier.issn1303-829X
dc.identifier.issn1303-829X
dc.identifier.issue6en_US
dc.identifier.startpage891en_US
dc.identifier.trdizinid455718en_US
dc.identifier.urihttps://doi.org/10.1515/tjb-2020-0073
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/455718
dc.identifier.urihttps://hdl.handle.net/11454/80246
dc.identifier.volume45en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofTürk Biyokimya Dergisien_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleAnalysis of blood gas beyond bicarbonate in outpatients with stage 3–5 chronic kidney diseaseen_US
dc.typeArticleen_US

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