Analysis of blood gas beyond bicarbonate in outpatients with stage 3–5 chronic kidney disease

Objectives: Metabolic acidosis is a common disorder seenin course of chronic kidney disease (CKD). In this study, weaimed to investigate the association of Base excess (BE),Anion gap (AG) and Delta Ratio with progression of CKD,renal replacement therapy (RRT) requirement and mortalityin patients with stage 3–5 CKD.Methods: A total of 212 patients with stage 3–5 CKD wereincluded in this study. Patients were divided into twogroups according to the baseline BE level. Patients werealso grouped according to the delta ratio such as non- AG,High AG and mixed type.Results: Mean BE level was significantly lower (?4.7 ± 4.0vs. ?3.3 ± 4.3; p=0.02) in patientswith CKD progression. Thepatients in group 1 (n: 130) (Be<?2.5) revealed more CKDprogression (%53 vs. %32; p=0.002), and RRT requirement(%35 vs.%15; p=0.001). Baseline BE <?2.5 (odds ratio, 0.38;95% CI, 0.16 to 0.91; p<0.05) and baseline GFR (odds ratio,0.94; 95% CI, 0.90 to 0.97; p<0.001) were independentlyrelated to RRT requirement. Delta BE was independentlyassociated with mortality (odds ratio, 0.90; 95% CI, 0.85–0.96; p<0.01).Conclusions: Low BE levels were associated with CKDprogression and RRT requirement. BE change is associatedwith mortality during the follow-up of thosepatients.