Investigation of acute effects of topical Alpinia officinarum (galangal) treatment in experimental contact type burns and comparison with topical silver sulfadiazine treatment

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dc.authoridCetin Uyanikgil, Emel Oyku/0000-0001-8822-9130
dc.authoridKadam, Koray/0000-0001-6720-2502
dc.authoridUyanikgil, Yigit/0000-0002-4016-0522
dc.authoriduyanikgil, Yigit/0000-0002-4016-0522
dc.authorscopusid57417182200
dc.authorscopusid15123207500
dc.authorscopusid6506580350
dc.authorscopusid55140289900
dc.authorscopusid25948152400
dc.authorwosidCetin Uyanikgil, Emel Oyku/M-4400-2019
dc.authorwosidKadam, Koray/B-9103-2019
dc.authorwosiduyanikgil, Yigit/K-3544-2017
dc.authorwosidUyanikgil, Yigit/M-2746-2019
dc.contributor.authorKadam, Koray
dc.contributor.authorKiyan, Selahattin
dc.contributor.authorUyanikgil, Yigit
dc.contributor.authorKarabey, Fatih
dc.contributor.authorCetin, Emel Oyku
dc.date.accessioned2023-01-12T20:10:51Z
dc.date.available2023-01-12T20:10:51Z
dc.date.issued2022
dc.departmentN/A/Departmenten_US
dc.description.abstractBACKGROUND: It was aimed to determine whether Alpinia officinarum (AO) (galangal), which has been regarded to be effective on wound healing, is healing on experimental contact type burns and compare its effects with silver sulfadiazine (SSD). METHODS: Thirty-five rats were divided into five groups of seven rats each group. Superficial second degree burns were formed by contacting a 1x1 cm copper tip which was kept at 100 degrees C constant temperature to the three shaved areas on the back of rats without applying any pressure for 10 s. All groups were irrigated with a 100 cc saline solution for 2 min. Any procedure or treatment was not applied to Group I (Control). Group II (Burn Control) was only irrigated, Group III (SSD) was applied topical SSD 4 times, with 6-h intervals (at h 0, 6, 12 and 18), Group IV (Galangal) was applied topical AO 4 times, and Group V (Gel) was applied placebo topical material, used for the preparation of topical AO, 4 times. Wound healing findings were evaluated histopathologically. RESULTS: In the galangal group, it was found that collagen discoloration didn't penetrate into deep dermis compared to other groups; epidermis, hair follicles, and sebaceous glands remained protected compared to the burn control group, and there was a thicker layer of epidermis. It was found that the galangal group was the closest group to the control group histologically. In the galangal group, it was determined that the number of vessels and total hair follicles were significantly higher in the 8th h and 4th h respectively (p<0.05), while epidermal thickness and number of degenerated hair follicles were significantly higher in all hours compared to other three groups (p<0.05). It was determined that galangal group had the lowest scores in the evaluation of edema, polymorphonuclear leukocytes infiltration, collagen discoloration, injury of vessels, hair follicles and sebaceous glands in comparisons between groups and within groups' own processes. CONCLUSION: Administrating AO containing gel 4 times a day within the first 24 h is effective in the experimental contact type second degree burn model. It is significantly superior to SSD treatment, especially in the first 8 h of administration.en_US
dc.description.sponsorshipEge University Scientific Research Projects Fund [2013TIP-027]en_US
dc.description.sponsorshipThis study was supported by the Ege University Scientific Research Projects Fund as project 2013TIP-027.en_US
dc.identifier.doi10.14744/tjtes.2020.69002
dc.identifier.endpage26en_US
dc.identifier.issn1306-696X
dc.identifier.issue1en_US
dc.identifier.pmid34967434en_US
dc.identifier.scopus2-s2.0-85123048224en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage15en_US
dc.identifier.trdizinid1137430en_US
dc.identifier.urihttps://doi.org/10.14744/tjtes.2020.69002
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1137430
dc.identifier.urihttps://hdl.handle.net/11454/77955
dc.identifier.volume28en_US
dc.identifier.wosWOS:000739854500003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTurkish Assoc Trauma Emergency Surgeryen_US
dc.relation.ispartofUlusal Travma Ve Acil Cerrahi Dergisi-Turkish Journal of Trauma & Emergency Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAlpinia officinarumen_US
dc.subjectburnen_US
dc.subjectgalangalen_US
dc.subjectsilver sulfadiazineen_US
dc.subjectwound healingen_US
dc.subjectFlavonoid Galanginen_US
dc.subjectGene-Expressionen_US
dc.subjectModelen_US
dc.subjectRaten_US
dc.subjectHoneyen_US
dc.subjectSkinen_US
dc.subjectManagementen_US
dc.subjectInhibitoren_US
dc.subjectWoundsen_US
dc.titleInvestigation of acute effects of topical Alpinia officinarum (galangal) treatment in experimental contact type burns and comparison with topical silver sulfadiazine treatmenten_US
dc.title.alternativeDeneysel temas tipi yanıklarda topikal Alpinia officinarum (havlıcan) tedavisinin akut etkilerinin araştırılması ve topikal gümüş sülfadiazin tedavisi ile karşılaştırılmasıen_US
dc.typeArticleen_US

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