Impact of Residual Mitral Regurgitation on Right Ventricular Systolic Function After Left Ventricular Assist Device Implantation

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dc.contributor.authorErtugay, Serkan
dc.contributor.authorKemal, Hatice S.
dc.contributor.authorKahraman, Umit
dc.contributor.authorEngin, Catagay
dc.contributor.authorNalbantgil, Sanem
dc.contributor.authorYagdi, Tahir
dc.contributor.authorOzbaran, Mustafa
dc.date.accessioned2019-10-27T11:06:59Z
dc.date.available2019-10-27T11:06:59Z
dc.date.issued2017
dc.departmentEge Üniversitesien_US
dc.description.abstractSignificant mitral regurgitation (MR) is thought to decrease after left ventricular assist device (LVAD) implantation, and therefore repair of mitral valve is not indicated in current practice. However, residual moderate and severe MR leads to pulmonary artery pressure increase, thereby resulting in right ventricular (RV) dysfunction during follow-up. We examined the impact of residual MR on systolic function of the right ventricle by echocardiography after LVAD implantation. This study included 90 patients (mean age: 51.7 +/- 10.9 years, 14.4% female) who underwent LVAD implantation (HeartMate II=21, HeartWare569) in a single center between December 2010 and June 2014. Echocardiograms obtained at 3-6 months and over after implantation were analyzed retrospectively. RV systolic function was graded as normal, mild, moderate, and severely depressed. MR (>= moderate) was observed in 43 and 44% of patients at early and late period, respectively. Systolic function of the RV was severely depressed in 16 and 9% of all patients. Initial analysis (mean duration of support 174.3 +/- 42.5 days) showed a statistically significant correlation between less MR and improved systolic function of RV (P=0.01). Secondary echocardiographic analysis (following a mean duration of support of 435.1 +/- 203 days) was also statistically significant for MR degree and RV systolic dysfunction (P= 0.008). Residual MR after LVAD implantation may cause deterioration of RV systolic function and cause right-sided heart failure symptoms. Repair of severe MR, in selected patients such as those with severe pulmonary hypertension and depressed RV, may be considered to improve the patient's clinical course during pump support.en_US
dc.identifier.doi10.1111/aor.12831en_US
dc.identifier.endpage627en_US
dc.identifier.issn0160-564X
dc.identifier.issn1525-1594
dc.identifier.issue7en_US
dc.identifier.pmid27873344en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage622en_US
dc.identifier.urihttps://doi.org/10.1111/aor.12831
dc.identifier.urihttps://hdl.handle.net/11454/31957
dc.identifier.volume41en_US
dc.identifier.wosWOS:000406982100005en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofArtificial Organsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLeft ventricular assist deviceen_US
dc.subjectRight heart failureen_US
dc.subjectMitral regurgitationen_US
dc.titleImpact of Residual Mitral Regurgitation on Right Ventricular Systolic Function After Left Ventricular Assist Device Implantationen_US
dc.typeArticleen_US

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