Impact of Residual Mitral Regurgitation on Right Ventricular Systolic Function After Left Ventricular Assist Device Implantation
Küçük Resim Yok
Tarih
2017
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wiley
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Significant mitral regurgitation (MR) is thought to decrease after left ventricular assist device (LVAD) implantation, and therefore repair of mitral valve is not indicated in current practice. However, residual moderate and severe MR leads to pulmonary artery pressure increase, thereby resulting in right ventricular (RV) dysfunction during follow-up. We examined the impact of residual MR on systolic function of the right ventricle by echocardiography after LVAD implantation. This study included 90 patients (mean age: 51.7 +/- 10.9 years, 14.4% female) who underwent LVAD implantation (HeartMate II=21, HeartWare569) in a single center between December 2010 and June 2014. Echocardiograms obtained at 3-6 months and over after implantation were analyzed retrospectively. RV systolic function was graded as normal, mild, moderate, and severely depressed. MR (>= moderate) was observed in 43 and 44% of patients at early and late period, respectively. Systolic function of the RV was severely depressed in 16 and 9% of all patients. Initial analysis (mean duration of support 174.3 +/- 42.5 days) showed a statistically significant correlation between less MR and improved systolic function of RV (P=0.01). Secondary echocardiographic analysis (following a mean duration of support of 435.1 +/- 203 days) was also statistically significant for MR degree and RV systolic dysfunction (P= 0.008). Residual MR after LVAD implantation may cause deterioration of RV systolic function and cause right-sided heart failure symptoms. Repair of severe MR, in selected patients such as those with severe pulmonary hypertension and depressed RV, may be considered to improve the patient's clinical course during pump support.
Açıklama
Anahtar Kelimeler
Left ventricular assist device, Right heart failure, Mitral regurgitation
Kaynak
Artificial Organs
WoS Q Değeri
Q2
Scopus Q Değeri
Q2
Cilt
41
Sayı
7
