Ulex Europeus Agglutinin (UEA-I) lectin binding in breast carcinoma and its relationship to prognostic factors

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dc.contributor.authorErhan, Y
dc.contributor.authorAlkanat, MB
dc.contributor.authorAkyildiz, M
dc.contributor.authorIcoz, G
dc.contributor.authorYilmaz, R
dc.contributor.authorErhan, Y
dc.date.accessioned2019-10-27T11:55:09Z
dc.date.available2019-10-27T11:55:09Z
dc.date.issued1996
dc.departmentEge Üniversitesien_US
dc.description.abstractIn this study, lectin binding was compared with pathological prognostic factors and clinical follow-up details. Formalin-fixed, paraffin-embedded tissues from 43 cases of breast carcinoma were studied for binding with Ulex Europeus Agglutinin (UEA-I) lectin. Staining results were compared with tumor size, histologic and nuclear grade, lymph node status (number, capsular and pericapsular invasion), blood and lymphatic vessel invasion, ER and PR status, clinical stage and the patients' short-term follow-up details. Analysis of staining with UEA-I showed a significant relationship with blood vessel invasion (P < 0.01) and lymphatic vessel invasion (P < 0.05). Furthermore, PR showed a significant inverse correlation with lectin binding (P < 0.05). Staining with UEA-I related significantly with axillary lymph node metastases (P < 0.05). UEA-I was positive in four (66.6%) out of six cases with distant organ metastasis. This study confirms that, in breast cancer, lectin binding to the cancer cells can be a reliable indicator for axillary metastases, and the need for additional therapeutic interventions.en_US
dc.identifier.doi10.5144/0256-4947.1996.509en_US
dc.identifier.endpage511en_US
dc.identifier.issn0256-4947
dc.identifier.issue5en_US
dc.identifier.pmid17429227en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage509en_US
dc.identifier.urihttps://doi.org/10.5144/0256-4947.1996.509
dc.identifier.urihttps://hdl.handle.net/11454/35107
dc.identifier.volume16en_US
dc.identifier.wosWOS:A1996VP76000005en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherK Faisal Spec Hosp Res Centreen_US
dc.relation.ispartofAnnals of Saudi Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleUlex Europeus Agglutinin (UEA-I) lectin binding in breast carcinoma and its relationship to prognostic factorsen_US
dc.typeArticleen_US

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