Ulex Europeus Agglutinin (UEA-I) lectin binding in breast carcinoma and its relationship to prognostic factors
Küçük Resim Yok
Tarih
1996
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
K Faisal Spec Hosp Res Centre
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
In this study, lectin binding was compared with pathological prognostic factors and clinical follow-up details. Formalin-fixed, paraffin-embedded tissues from 43 cases of breast carcinoma were studied for binding with Ulex Europeus Agglutinin (UEA-I) lectin. Staining results were compared with tumor size, histologic and nuclear grade, lymph node status (number, capsular and pericapsular invasion), blood and lymphatic vessel invasion, ER and PR status, clinical stage and the patients' short-term follow-up details. Analysis of staining with UEA-I showed a significant relationship with blood vessel invasion (P < 0.01) and lymphatic vessel invasion (P < 0.05). Furthermore, PR showed a significant inverse correlation with lectin binding (P < 0.05). Staining with UEA-I related significantly with axillary lymph node metastases (P < 0.05). UEA-I was positive in four (66.6%) out of six cases with distant organ metastasis. This study confirms that, in breast cancer, lectin binding to the cancer cells can be a reliable indicator for axillary metastases, and the need for additional therapeutic interventions.
Açıklama
Anahtar Kelimeler
Kaynak
Annals of Saudi Medicine
WoS Q Değeri
N/A
Scopus Q Değeri
Q3
Cilt
16
Sayı
5
