CSF levels of a set of neurotrophic factors (brain-derived neurotrophic factor, nerve growth factor) and neuropeptides (neuropeptide Y, galanin) in epileptic children

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dc.contributor.authorTekgul, Hasan
dc.contributor.authorSerin, Hepsen Mine
dc.contributor.authorSimsek, Erdem
dc.contributor.authorKanmaz, Seda
dc.contributor.authorGazeteci, Hande
dc.contributor.authorAzarsiz, Elif
dc.contributor.authorGokben, Sarenur
dc.date.accessioned2020-12-01T12:01:08Z
dc.date.available2020-12-01T12:01:08Z
dc.date.issued2020
dc.departmentEge Üniversitesien_US
dc.description.abstractThis paper aims to investigate the possible roles of a set of neurotrophic factors (brain-derived neurotrophic factor-BDNF, nerve growth factor-NGF) and neuropeptides (neuropeptide Y-NPY, and galanin) in children with active epileptogenesis. the cerebrospinal fluid (CSF) levels of BDNF, NPY, NGF and galanin were measured with enzyme-linked immunosorbent assays in epileptic children (n = 73) and controls (n = 64). There were no significant alterations in the CSF levels of BDNF, NPY and NGF in epileptic children with active clinical seizures compared with the levels of controls. However profoundly depressed galanin levels were found in infants with epileptic encephalopathy (mean +/- SD:0.63 +/- 0.19 pg/ml) and significantly increased galanin levels were measured in children with drug resistant epilepsy during the period of status epilepticus (mean +/- SD: 6.92 +/- 1.19, pg/ml pg/ml) compared with the levels of controls. Depressed levels of galanin might reflect a defective anti-epileptogenic effect of galanin in infants with epileptic encephalopathy. on the contrary, increased CSF levels of galanin might be a result of antiepileptogenic effects of this peptide in epileptic children with status epilepticus. (C) 2020 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.jocn.2020.04.064en_US
dc.identifier.endpage45en_US
dc.identifier.issn0967-5868
dc.identifier.issn1532-2653
dc.identifier.pmid32327377en_US
dc.identifier.scopus2-s2.0-85083356803en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage41en_US
dc.identifier.urihttps://doi.org/10.1016/j.jocn.2020.04.064
dc.identifier.urihttps://hdl.handle.net/11454/62309
dc.identifier.volume76en_US
dc.identifier.wosWOS:000537834300009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Sci Ltden_US
dc.relation.ispartofJournal of Clinical Neuroscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBrain derived neurotrophic factoren_US
dc.subjectEpilepsyen_US
dc.subjectEpileptogenesisen_US
dc.subjectGalaninen_US
dc.subjectNerve growth factoren_US
dc.subjectNeuropeptide Yen_US
dc.titleCSF levels of a set of neurotrophic factors (brain-derived neurotrophic factor, nerve growth factor) and neuropeptides (neuropeptide Y, galanin) in epileptic childrenen_US
dc.typeArticleen_US

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