CSF levels of a set of neurotrophic factors (brain-derived neurotrophic factor, nerve growth factor) and neuropeptides (neuropeptide Y, galanin) in epileptic children
Küçük Resim Yok
Tarih
2020
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier Sci Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
This paper aims to investigate the possible roles of a set of neurotrophic factors (brain-derived neurotrophic factor-BDNF, nerve growth factor-NGF) and neuropeptides (neuropeptide Y-NPY, and galanin) in children with active epileptogenesis. the cerebrospinal fluid (CSF) levels of BDNF, NPY, NGF and galanin were measured with enzyme-linked immunosorbent assays in epileptic children (n = 73) and controls (n = 64). There were no significant alterations in the CSF levels of BDNF, NPY and NGF in epileptic children with active clinical seizures compared with the levels of controls. However profoundly depressed galanin levels were found in infants with epileptic encephalopathy (mean +/- SD:0.63 +/- 0.19 pg/ml) and significantly increased galanin levels were measured in children with drug resistant epilepsy during the period of status epilepticus (mean +/- SD: 6.92 +/- 1.19, pg/ml pg/ml) compared with the levels of controls. Depressed levels of galanin might reflect a defective anti-epileptogenic effect of galanin in infants with epileptic encephalopathy. on the contrary, increased CSF levels of galanin might be a result of antiepileptogenic effects of this peptide in epileptic children with status epilepticus. (C) 2020 Elsevier Ltd. All rights reserved.
Açıklama
Anahtar Kelimeler
Brain derived neurotrophic factor, Epilepsy, Epileptogenesis, Galanin, Nerve growth factor, Neuropeptide Y
Kaynak
Journal of Clinical Neuroscience
WoS Q Değeri
Q4
Scopus Q Değeri
Q2
Cilt
76
