A new approach for in vitro imaging of breast cancer cells by anti-metadherin targeted PVA-pyrene

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dc.contributor.authorMedine E.I.
dc.contributor.authorOdaci D.
dc.contributor.authorGacal B.N.
dc.contributor.authorGacal B.
dc.contributor.authorSakarya S.
dc.contributor.authorUnak P.
dc.contributor.authorTimur S.
dc.contributor.authorYagci Y.
dc.date.accessioned2019-10-27T08:34:48Z
dc.date.available2019-10-27T08:34:48Z
dc.date.issued2010
dc.departmentEge Üniversitesien_US
dc.description.abstractPoly(vinyl alcohol)-pyrene-anti-metadherin (PVA-Py-(Anti-MTDH)), a novel antibody based water soluble probe containing both fluorescent and target sites in the structure for in vitro imaging of breast cancer cells is reported here. Since breast cancer cells have an excess of MDTH protein expressed on the surface, a PVA-Py prepared by "Click chemistry" approach is targeted by Anti-MTDH antibody and applied to the MCF-7 cell line. After characterization, the designed architecture was evaluated in terms of cell incorporation efficiency and compared with a non-targeted structure (PVA-Py). Atomic force microscopy (AFM) and fluorescence microscopy images of cells after incubation of the probe molecules were also obtained to monitor the interaction of the probes with the cancerous cells. (Figure Presented). © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.en_US
dc.identifier.doi10.1002/mabi.201000009en_US
dc.identifier.endpage663en_US
dc.identifier.issn1616-5187
dc.identifier.issue6en_US
dc.identifier.pmid20336700en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage657en_US
dc.identifier.urihttps://doi.org/10.1002/mabi.201000009
dc.identifier.urihttps://hdl.handle.net/11454/27113
dc.identifier.volume10en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWiley-VCH Verlagen_US
dc.relation.ispartofMacromolecular Bioscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDrug delivery systemsen_US
dc.subjectFluorescenceen_US
dc.subjectFunctionalization of polymersen_US
dc.subjectImagingen_US
dc.subjectSynthesisen_US
dc.titleA new approach for in vitro imaging of breast cancer cells by anti-metadherin targeted PVA-pyreneen_US
dc.typeArticleen_US

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