A study on the protective activity of kefir against gastric ulcer

Basit Öğe Kaydı
dc.contributor.authorOrhan Y.T.
dc.contributor.authorKaragözlü C.
dc.contributor.authorSarioglu S.
dc.contributor.authorYilmaz O.
dc.contributor.authorMurat N.
dc.contributor.authorGidener S.
dc.date.accessioned2019-10-26T21:45:38Z
dc.date.available2019-10-26T21:45:38Z
dc.date.issued2012
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground/aims: The effect of kefir on peptic ulcer disease was evaluated in an experimental model, with non-steroid anti-inflammatory drugs, together with the determination of gastric mucus secretion by quantitative digital histochemistry. Materials and Methods: The experimental group included 28 male albino Wistar rats. After a diet with standard rat bait for 7 days, 14 rats were fed with kefir for 7 days while the others were kept on the same diet. At the 14th day, indomethacin was injected to 7 of the rats fed on kefir and to 7 of the rats on standard rat bait. All the rats were sacrificed after 4 hours. Gastric erosion and ulceration were scored histopathologically. Mucosal mucus was quantified by image analysis, and periodic acid-Schiff stained area percentage was determined. Results: Erosion and ulceration were identified only in cases that received indomethacin. In the cases on kefir, erosion was identified in 6 cases (86%) and ulceration in 1 case. Rats fed on standard diet had erosion in 4 cases (57%) and ulceration in 3 (43%), but the difference was statistically insignificant (Mann-Whitney test, p=0.25). The stained area percentage for gastric mucus was not different between the four groups (Kruskal-Wallis test, p=0.313). Conclusions: These findings suggest that kefir does not change gastric mucus secretion. Although statistically insignificant, as there were more cases with ulceration in cases on the rat diet, kefir might have a beneficial effect on peptic ulcer disease induced by non-steroid anti-inflammatory drug. This requires further evaluation in larger series.en_US
dc.identifier.doi10.4318/tjg.2012.0343
dc.identifier.endpage338en_US
dc.identifier.issn1300-4948
dc.identifier.issue4en_US
dc.identifier.pmid22965503en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage333en_US
dc.identifier.urihttps://doi.org/10.4318/tjg.2012.0343
dc.identifier.urihttps://hdl.handle.net/11454/18518
dc.identifier.volume23en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofTurkish Journal of Gastroenterologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGastric ulceren_US
dc.subjectImage analysisen_US
dc.subjectKefiren_US
dc.subjectProbioticsen_US
dc.titleA study on the protective activity of kefir against gastric ulceren_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
TR-Dizin İndeksli Yayınlar Koleksiyonu