Amniotic Membrane Transplantation in Surgical Treatment of Conjunctival Melanoma: Long-term Results

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dc.contributor.authorPalamar, Melis
dc.contributor.authorYaman, Banu
dc.contributor.authorAkalin, Taner
dc.contributor.authorYagci, Ayse
dc.date.accessioned2019-10-27T10:42:56Z
dc.date.available2019-10-27T10:42:56Z
dc.date.issued2018
dc.departmentEge Üniversitesien_US
dc.description.abstractObjectives: To investigate the long-term efficacy and results of surgical management of conjunctival melanoma reconstructed with amniotic membrane transplantation. Materials and Methods: Conjunctival melanoma in 10 patients (5 female, 5 male) was totally excised with adjunctive cryotherapy to the surgical margins, corneal epitheliectomy with absolute alcohol in cases of corneal involvement, lamellar sclerectomy in cases with episcleral involvement, and ocular surface grafting with cryopreserved amniotic membrane. Complications and tumor control rates were evaluated. Results: The mean age of the patients was 57.4 +/- 15.2 (range, 37-84) years. The mean diameter of the tumors was 15.5 +/- 4.9 (range, 10-25) mm and histopathologically confirmed complete excision was performed in all cases. Mild limbal stem cell deficiency (2 eyes) and subclinical symblepharon (3 eyes) were observed as long-term complications. In a mean follow-up of 56.7 +/- 40.4 (range, 30-132) months, only one local tumor recurrence was detected. Despite retreatment, exenteration was performed in this patient due to re-recurrence. One patient died due to disseminated metastasis despite the absence of local recurrence. Conclusion: In large conjunctival melanomas, reconstruction of the ocular surface is usually very challenging. The use of cryopreserved amniotic membrane for conjunctival defect repair is safe and effective with mild complications, and allows the excision of wider margins around the tumor.en_US
dc.identifier.doi10.4274/tjo.62681
dc.identifier.endpage18en_US
dc.identifier.issn1300-0659
dc.identifier.issn2147-2661
dc.identifier.issue1en_US
dc.identifier.pmid29576892en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage15en_US
dc.identifier.urihttps://doi.org/10.4274/tjo.62681
dc.identifier.urihttps://hdl.handle.net/11454/30699
dc.identifier.volume48en_US
dc.identifier.wosWOS:000429421300004en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTurkish Ophthalmological Socen_US
dc.relation.ispartofTurk Oftalmoloji Dergisi-Turkish Journal of Ophthalmologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAmniotic membraneen_US
dc.subjectconjunctivaen_US
dc.subjectcryotherapyen_US
dc.subjectmelanomaen_US
dc.subjecttumoren_US
dc.titleAmniotic Membrane Transplantation in Surgical Treatment of Conjunctival Melanoma: Long-term Resultsen_US
dc.typeArticleen_US

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