CYTOTOXIC AND ANTIMICROBIAL ACTIVITIES OF PTILOSTEMON CHAMAEPEUCE (L.) LESS

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dc.authorscopusid36988052000
dc.authorscopusid55588677300
dc.authorscopusid55823702000
dc.authorscopusid6504012138
dc.authorscopusid35558727300
dc.contributor.authorDemir, S.
dc.contributor.authorErzurumlu, Y.
dc.contributor.authorÖztürk, İ.
dc.contributor.authorBallar, Kirmizibayrak, P.
dc.contributor.authorKaraalp, C.
dc.date.accessioned2024-08-25T18:38:15Z
dc.date.available2024-08-25T18:38:15Z
dc.date.issued2022
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective: The aim of this study is to investigate the antimicrobial and cytotoxic activities of n-hexane chloroform and methanol extracts prepared from the aerial parts of P. chamaepeuce (L.) Less. (Asteraceae). Material and Method: The antimicrobial activities of the extracts on standard bacterial strains (Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, Salmonella enterica, Pseudomonas aeruginosa, Bacillus subtilis and Streptococcus pneumoniae) and fungal strains (Candida albicans and C. parapsilosis) were examined by microdilution method and minimum inhibitory concentration (MIC) values were determined. The cytotoxic activity of the extracts was investigated by cell proliferation assay using WST-1 reagent on various cancer cell lines including HeLa, U2OS, PC3, MCF-7, and A549 cancer cell lines. Result and Discussion: The MIC values of n-hexane, chloroform and methanol extracts were between 250-1000 µg/mL against S. aureus, E. faecalis and B. subtilis. n-hexane and chloroform extracts had varying levels of cytotoxic activity in all tested cancer cell lines (IC50: 21.0-67.1 ?g/mL). © 2022 University of Ankara. All rights reserved.en_US
dc.identifier.doi10.33483/jfpau.1100161
dc.identifier.endpage702en_US
dc.identifier.issn1015-3918
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85149931209en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage694en_US
dc.identifier.trdizinid1134029en_US
dc.identifier.urihttps://doi.org/10.33483/jfpau.1100161
dc.identifier.urihttps://hdl.handle.net/11454/100914
dc.identifier.volume46en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isotren_US
dc.publisherUniversity of Ankaraen_US
dc.relation.ispartofAnkara Universitesi Eczacilik Fakultesi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240825_Gen_US
dc.subjectAntimicrobial activityen_US
dc.subjectcytotoxicityen_US
dc.subjectPtilostemon chamaepeuceen_US
dc.subjectchloroformen_US
dc.subjecthexaneen_US
dc.subjectmethanolen_US
dc.subjectplant extracten_US
dc.subjectPtilostemon chamaepeuce extracten_US
dc.subjectunclassified drugen_US
dc.subjectaerial plant parten_US
dc.subjectantimicrobial activityen_US
dc.subjectArticleen_US
dc.subjectAsteraceaeen_US
dc.subjectBacillus subtilisen_US
dc.subjectbacterial strainen_US
dc.subjectcancer cell lineen_US
dc.subjectCandida albicansen_US
dc.subjectCandida parapsilosisen_US
dc.subjectcell proliferation assayen_US
dc.subjectcytotoxicityen_US
dc.subjectEnterococcus faecalisen_US
dc.subjectEscherichia colien_US
dc.subjectfungal strainen_US
dc.subjecthumanen_US
dc.subjecthuman cellen_US
dc.subjectminimum inhibitory concentrationen_US
dc.subjectnonhumanen_US
dc.subjectPseudomonas aeruginosaen_US
dc.subjectPtilostemon chamaepeuceen_US
dc.subjectSalmonella entericaen_US
dc.subjectsolvent extractionen_US
dc.subjectStaphylococcus aureusen_US
dc.subjectStreptococcus pneumoniaeen_US
dc.titleCYTOTOXIC AND ANTIMICROBIAL ACTIVITIES OF PTILOSTEMON CHAMAEPEUCE (L.) LESSen_US
dc.title.alternativePTILOSTEMON CHAMAEPEUCE (L.) LESS.’İN SİTOTOKSİK VE ANTİMİKROBİYAL AKTİVİTESİen_US
dc.typeArticleen_US

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