CYTOTOXIC AND ANTIMICROBIAL ACTIVITIES OF PTILOSTEMON CHAMAEPEUCE (L.) LESS
Küçük Resim Yok
Tarih
2022
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
University of Ankara
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: The aim of this study is to investigate the antimicrobial and cytotoxic activities of n-hexane chloroform and methanol extracts prepared from the aerial parts of P. chamaepeuce (L.) Less. (Asteraceae). Material and Method: The antimicrobial activities of the extracts on standard bacterial strains (Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, Salmonella enterica, Pseudomonas aeruginosa, Bacillus subtilis and Streptococcus pneumoniae) and fungal strains (Candida albicans and C. parapsilosis) were examined by microdilution method and minimum inhibitory concentration (MIC) values were determined. The cytotoxic activity of the extracts was investigated by cell proliferation assay using WST-1 reagent on various cancer cell lines including HeLa, U2OS, PC3, MCF-7, and A549 cancer cell lines. Result and Discussion: The MIC values of n-hexane, chloroform and methanol extracts were between 250-1000 µg/mL against S. aureus, E. faecalis and B. subtilis. n-hexane and chloroform extracts had varying levels of cytotoxic activity in all tested cancer cell lines (IC50: 21.0-67.1 ?g/mL). © 2022 University of Ankara. All rights reserved.
Açıklama
Anahtar Kelimeler
Antimicrobial activity, cytotoxicity, Ptilostemon chamaepeuce, chloroform, hexane, methanol, plant extract, Ptilostemon chamaepeuce extract, unclassified drug, aerial plant part, antimicrobial activity, Article, Asteraceae, Bacillus subtilis, bacterial strain, cancer cell line, Candida albicans, Candida parapsilosis, cell proliferation assay, cytotoxicity, Enterococcus faecalis, Escherichia coli, fungal strain, human, human cell, minimum inhibitory concentration, nonhuman, Pseudomonas aeruginosa, Ptilostemon chamaepeuce, Salmonella enterica, solvent extraction, Staphylococcus aureus, Streptococcus pneumoniae
Kaynak
Ankara Universitesi Eczacilik Fakultesi Dergisi
WoS Q Değeri
Scopus Q Değeri
Q4
Cilt
46
Sayı
3
