Beneficial effects of agomelatine in experimental model of sepsis-related acute kidney injury

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dc.contributor.authorBasol, Nursah
dc.contributor.authorErbas, Oytun
dc.contributor.authorCavusoglu, Turker
dc.contributor.authorMeral, Ayfer
dc.contributor.authorAtes, Utku
dc.date.accessioned2019-10-27T23:10:56Z
dc.date.available2019-10-27T23:10:56Z
dc.date.issued2016
dc.departmentEge Üniversitesien_US
dc.description.abstractBACKGROUND: Sepsis-related acute kidney injury (AKI) is a serious complication of sepsis. Problems persist regarding early diagnosis and treatment of AKI. The aim of the present study was to evaluate the efficacy of agomelatine, which is primarily known for its positive effects on depressive and anxiety disorders in sepsis-related AKI. METHODS: Sepsis model was created with cecal ligation puncture (CLP). Rats were separated into 4 groups of 8 each: the control group, the sham-operated group, the CLP+saline group, and the CLP+agomelatine group. Agomelatine was administered intraperitoneally in doses of 20 mg/kg. RESULTS: In the agomelatine group, reductions were observed in levels of tumor necrosis factor alpha (TNF-alpha), malondialdehyde (MDA), blood urea nitrogen (BUN), and creatinine, as well as in histological kidney scores, compared to the non-treated group. In addition, it was demonstrated that agomelatine treatment had positive effect on sepsis-induced morphological damage to renal and tubular tissues. CONCLUSION: Agomelatine showed strong efficacy in sepsis-related AKI, demonstrated with histological and biochemical results in an experimental model. It is believed that antioxidant and pro-inflammatory effects of agomelatine are responsible for the improvement in kidneys.en_US
dc.identifier.doi10.5505/tjtes.2015.29499
dc.identifier.endpage126en_US
dc.identifier.issn1306-696X
dc.identifier.issue2en_US
dc.identifier.pmid27193977en_US
dc.identifier.startpage121en_US
dc.identifier.urihttps://doi.org/10.5505/tjtes.2015.29499
dc.identifier.urihttps://hdl.handle.net/11454/52988
dc.identifier.volume22en_US
dc.identifier.wosWOS:000374753400002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTurkish Assoc Trauma Emergency Surgeryen_US
dc.relation.ispartofUlusal Travma Ve Acil Cerrahi Dergisi-Turkish Journal of Trauma & Emergency Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcute kidney injuryen_US
dc.subjectagomelatineen_US
dc.subjectcecal ligation punctureen_US
dc.subjectsepsisen_US
dc.titleBeneficial effects of agomelatine in experimental model of sepsis-related acute kidney injuryen_US
dc.typeArticleen_US

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