Effect of omeprazole on plasma zinc levels after oral zinc administration

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dc.contributor.authorOzutemiz A.O.
dc.contributor.authorAydin H.H.
dc.contributor.authorIsler M.
dc.contributor.authorCelik H.A.K.
dc.contributor.authorBatur Y.
dc.date.accessioned2019-10-27T00:24:08Z
dc.date.available2019-10-27T00:24:08Z
dc.date.issued2002
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground: The intestines are the major site of zinc absorption and excretion. Reduced gastric acid secretion and elevated gastric pH is an important factor affecting intestinal mineral absorption. Methods: Gastric pH and volume, and basal and maximal acid outputs were measured in 14 healthy volunteers. Plasma zinc levels were then measured at baseline and 1, 2, 3 and 4 hours after oral administration of 300 mg zinc sulfate. The experiment was repeated after omeprazole administration (60 mg/day orally) for 7 days. Results: Omeprazole administration significantly increased fasting gastric pH (5.5 versus 2.4; p<0.001). Mean basal gastric acid output (1.6 vs 8.0 mEq/h; p<0.001) and maximal acid output (20.6 vs 106.6 mEq/h; p<0.001) decreased after omeprazole administration. Zinc absorption decreased after omeprazole administration (141 [34] mg/dL/h) compared with pre-omeprazole values (245 [35]; p<0.01). Conclusion: Suppression of gastric acid secretion by omeprazole reduces intestinal absorption of zinc.en_US
dc.identifier.endpage218en_US
dc.identifier.issn0254-8860
dc.identifier.issue6en_US
dc.identifier.pmid12546170en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage216en_US
dc.identifier.urihttps://hdl.handle.net/11454/22997
dc.identifier.volume21en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofIndian Journal of Gastroenterologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOmeprazoleen_US
dc.subjectZinc absorptionen_US
dc.titleEffect of omeprazole on plasma zinc levels after oral zinc administrationen_US
dc.typeArticleen_US

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