Effect of omeprazole on plasma zinc levels after oral zinc administration
Küçük Resim Yok
Tarih
2002
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background: The intestines are the major site of zinc absorption and excretion. Reduced gastric acid secretion and elevated gastric pH is an important factor affecting intestinal mineral absorption. Methods: Gastric pH and volume, and basal and maximal acid outputs were measured in 14 healthy volunteers. Plasma zinc levels were then measured at baseline and 1, 2, 3 and 4 hours after oral administration of 300 mg zinc sulfate. The experiment was repeated after omeprazole administration (60 mg/day orally) for 7 days. Results: Omeprazole administration significantly increased fasting gastric pH (5.5 versus 2.4; p<0.001). Mean basal gastric acid output (1.6 vs 8.0 mEq/h; p<0.001) and maximal acid output (20.6 vs 106.6 mEq/h; p<0.001) decreased after omeprazole administration. Zinc absorption decreased after omeprazole administration (141 [34] mg/dL/h) compared with pre-omeprazole values (245 [35]; p<0.01). Conclusion: Suppression of gastric acid secretion by omeprazole reduces intestinal absorption of zinc.
Açıklama
Anahtar Kelimeler
Omeprazole, Zinc absorption
Kaynak
Indian Journal of Gastroenterology
WoS Q Değeri
Scopus Q Değeri
Q3
Cilt
21
Sayı
6
