Polycythaemia in Infants of Diabetic Mothers: beta-Hydroxybutyrate Stimulates Erythropoietic Activity

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dc.contributor.authorCetin, H.
dc.contributor.authorYalaz, M.
dc.contributor.authorAkisu, M.
dc.contributor.authorKultursay, N.
dc.date.accessioned2019-10-27T21:24:17Z
dc.date.available2019-10-27T21:24:17Z
dc.date.issued2011
dc.departmentEge Üniversitesien_US
dc.description.abstractThis study tested whether elevated maternal beta-hydroxybutyrate (beta-OHB) levels contribute to polycythaemia in infants of diabetic mothers. Pregnant diabetic women (n = 27) and non-diabetic controls (n = 20) and their singleton infants were included. Maternal glycosylated haemoglobin and beta-OHB levels were studied at 34 - 36 weeks' gestation; levels were significantly higher in mothers with diabetes than in controls. Birth weights and cord blood levels of insulin and fetal haemoglobin were significantly higher in infants from diabetic mothers compared with control infants, as were haematocrit levels in venous blood samples taken from each infant at 4 h following delivery. Cord blood erythropoietin levels were similar in both groups. There was a positive strong correlation between maternal beta-OHB levels and polycythaemia in newborn infants, indicating that beta-OHB could activate erythropoiesis independently from intrauterine hyperinsulinaemia and/or erythropoietin levels, and may be important in the pathogenesis of polycythaemia in infants born to diabetic mothers.en_US
dc.identifier.doi10.1177/147323001103900314en_US
dc.identifier.endpage821en_US
dc.identifier.issn0300-0605
dc.identifier.issue3en_US
dc.identifier.pmid21819713en_US
dc.identifier.startpage815en_US
dc.identifier.urihttps://doi.org/10.1177/147323001103900314
dc.identifier.urihttps://hdl.handle.net/11454/44470
dc.identifier.volume39en_US
dc.identifier.wosWOS:000293990700014en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherField House Publishing Llpen_US
dc.relation.ispartofJournal of International Medical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPOLYCYTHAEMIAen_US
dc.subjectbeta-HYDROXYBUTYRATEen_US
dc.subjectINFANTS OF DIABETIC MOTHERSen_US
dc.subjectFETAL HAEMOGLOBINen_US
dc.subjectERYTHROPOIESISen_US
dc.titlePolycythaemia in Infants of Diabetic Mothers: beta-Hydroxybutyrate Stimulates Erythropoietic Activityen_US
dc.typeArticleen_US

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