Polycythaemia in Infants of Diabetic Mothers: beta-Hydroxybutyrate Stimulates Erythropoietic Activity
Küçük Resim Yok
Tarih
2011
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Field House Publishing Llp
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
This study tested whether elevated maternal beta-hydroxybutyrate (beta-OHB) levels contribute to polycythaemia in infants of diabetic mothers. Pregnant diabetic women (n = 27) and non-diabetic controls (n = 20) and their singleton infants were included. Maternal glycosylated haemoglobin and beta-OHB levels were studied at 34 - 36 weeks' gestation; levels were significantly higher in mothers with diabetes than in controls. Birth weights and cord blood levels of insulin and fetal haemoglobin were significantly higher in infants from diabetic mothers compared with control infants, as were haematocrit levels in venous blood samples taken from each infant at 4 h following delivery. Cord blood erythropoietin levels were similar in both groups. There was a positive strong correlation between maternal beta-OHB levels and polycythaemia in newborn infants, indicating that beta-OHB could activate erythropoiesis independently from intrauterine hyperinsulinaemia and/or erythropoietin levels, and may be important in the pathogenesis of polycythaemia in infants born to diabetic mothers.
Açıklama
Anahtar Kelimeler
POLYCYTHAEMIA, beta-HYDROXYBUTYRATE, INFANTS OF DIABETIC MOTHERS, FETAL HAEMOGLOBIN, ERYTHROPOIESIS
Kaynak
Journal of International Medical Research
WoS Q Değeri
Q4
Scopus Q Değeri
Cilt
39
Sayı
3
