Prospective evaluation of vascular changes in acute respiratory infections in children with cystic fibrosis

Basit Öğe Kaydı
dc.contributor.authorÖztürk, Gökçen
dc.contributor.authorEşki, Aykut
dc.contributor.authorÇelik, Figen
dc.contributor.authorConkar, Seçil
dc.contributor.authorGülen, Figen
dc.contributor.authorDemir, Esen
dc.contributor.authorKeskinoğlu, Ahmet
dc.date.accessioned2021-05-03T21:13:58Z
dc.date.available2021-05-03T21:13:58Z
dc.date.issued2020
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground/aim: Acute exacerbations and chronic inflammation are risk factors for cardiovascular disease (CVD) in cystic fibrosis (CF) patients. The aim of this study was to investigate the effects of acute exacerbation therapy on arterial stiffness in children with CF. Materials and methods: Augmentation index (Aix) and pulse wave velocity (PWV) were measured before and after treatment and 1 month after the end of treatment in patients with acute exacerbation. The relationship between hemodynamic measurements and c-reactive protein (CRP) and pulmonary function tests (PFTs) was investigated. Results: Measurements before and after treatment were evaluated in 27 patients and were repeated in 21 patients who were clinically stable 1 month following acute exacerbation. There was a significant decrease in CRP and an increase in spirometry parameters after treatment. While no significant difference was found between PWV (P = 0.33), a significant difference for Aix before (41.95 ± 12.96%) and after (30.95 ± 11.47%) treatment and before treatment and stable clinical condition (34.19 ± 14.36%) was obtained (P =0.00, and P =0.01, respectively). No significant difference in heart rate and other hemodynamic measurements was found. Pretreatment Aix is associated with poor clinical condition (PFTs, BMI, and clinical score) and systemic inflammation (CRP) (P <0.05). Conclusion: The decrease of arterial stiffness (Aix) with acute exacerbation treatment in children with CF has been demonstrated. This result shows that systemic inflammation in CF may cause an increase in arterial stiffness and recurrent exacerbations may increase the risk of CVD.en_US
dc.identifier.doi10.3906/sag-2002-61
dc.identifier.endpage1014en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue4en_US
dc.identifier.startpage1007en_US
dc.identifier.trdizinid354715en_US
dc.identifier.urihttps://doi.org/10.3906/sag-2002-61
dc.identifier.urihttps://hdl.handle.net/11454/71702
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/354715
dc.identifier.volume50en_US
dc.identifier.wosWOS:000613005100048en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofTurkish Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject[No Keywords]en_US
dc.titleProspective evaluation of vascular changes in acute respiratory infections in children with cystic fibrosisen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

TR-Dizin İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu