Investigation of Bioactivity of Estragole Isolated from Basil Plant on Brain Cancer Cell Lines Using Nuclear Method
dc.authorid | KARATAY, Kadriye Busra/0000-0002-2811-4689 | |
dc.authorscopusid | 24172536600 | |
dc.authorscopusid | 58307041600 | |
dc.authorscopusid | 57216968604 | |
dc.authorscopusid | 36187604000 | |
dc.authorscopusid | 57192664561 | |
dc.contributor.author | Avcibasi, Ugur | |
dc.contributor.author | Dewa, Mouhaman Toukour | |
dc.contributor.author | Karatay, Kadriye Busra | |
dc.contributor.author | Kilcar, Ayfer Yurt | |
dc.contributor.author | Muftuler, Fazilet Zumrut Biber | |
dc.date.accessioned | 2024-08-25T18:47:56Z | |
dc.date.available | 2024-08-25T18:47:56Z | |
dc.date.issued | 2023 | |
dc.department | Ege Üniversitesi | en_US |
dc.description.abstract | Background In recent years, there has been a significant increase in studies investigating the potential use of plant-origin products in the treatment and diagnosis of different types of cancer. Methods In this study, Estragole (EST) was isolated from basil leaves via ethanolic extraction using an 80% ethanol concentration. The isolation process was performed using the High Performance Liquid Chromatography (HPLC) method. The EST isolated from the basil plant was radiolabeled with I-131 using the iodogen method. Quality control studies of the radiolabeled EST (I-131-EST) were carried out by using Thin Layer Radio Chromatography (TLRC). Next, in vitro cell, culture studies were done to investigate the bio-affinity of plant-originated EST labeled with I-131 on human medulloblastoma (DAOY) and human glioblastoma-astrocytoma (U-87 MG) cell lines. Finally, the cytotoxicity of EST was determined, and cell uptake of I-131-EST was investigated on cancer cell lines by incorporation studies. Results As a result of these studies, it has been shown that I-131-EST has a significant uptake on the brain cells. Conclusion This result is very satisfying, and it has encouraged us to do in vivo studies for the molecule in the future. | en_US |
dc.identifier.doi | 10.2174/1874471016666230110144021 | |
dc.identifier.endpage | 150 | en_US |
dc.identifier.issn | 1874-4710 | |
dc.identifier.issn | 1874-4729 | |
dc.identifier.issue | 2 | en_US |
dc.identifier.pmid | 36627786 | en_US |
dc.identifier.scopus | 2-s2.0-85161263538 | en_US |
dc.identifier.scopusquality | Q3 | en_US |
dc.identifier.startpage | 140 | en_US |
dc.identifier.uri | https://doi.org/10.2174/1874471016666230110144021 | |
dc.identifier.uri | https://hdl.handle.net/11454/102099 | |
dc.identifier.volume | 16 | en_US |
dc.identifier.wos | WOS:001015585300006 | en_US |
dc.identifier.wosquality | Q3 | en_US |
dc.indekslendigikaynak | Web of Science | en_US |
dc.indekslendigikaynak | Scopus | en_US |
dc.indekslendigikaynak | PubMed | en_US |
dc.language.iso | en | en_US |
dc.publisher | Bentham Science Publ Ltd | en_US |
dc.relation.ispartof | Current Radiopharmaceuticals | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.snmz | 20240825_G | en_US |
dc.subject | Basil plant | en_US |
dc.subject | estragole (EST) | en_US |
dc.subject | iodine-131 (I-131) | en_US |
dc.subject | estragole radiolabeled with I-131 (I-131-EST) | en_US |
dc.subject | human medulloblastoma (DAOY) | en_US |
dc.subject | human glioblastoma-astrocytoma (U87-MG) | en_US |
dc.subject | Medicinal-Plants | en_US |
dc.subject | Biodistribution | en_US |
dc.subject | Leaves | en_US |
dc.subject | I-131 | en_US |
dc.subject | Radioiodination | en_US |
dc.subject | Perspective | en_US |
dc.subject | Morphine | en_US |
dc.title | Investigation of Bioactivity of Estragole Isolated from Basil Plant on Brain Cancer Cell Lines Using Nuclear Method | en_US |
dc.type | Article | en_US |