Investigation of Bioactivity of Estragole Isolated from Basil Plant on Brain Cancer Cell Lines Using Nuclear Method

dc.authoridKARATAY, Kadriye Busra/0000-0002-2811-4689
dc.authorscopusid24172536600
dc.authorscopusid58307041600
dc.authorscopusid57216968604
dc.authorscopusid36187604000
dc.authorscopusid57192664561
dc.contributor.authorAvcibasi, Ugur
dc.contributor.authorDewa, Mouhaman Toukour
dc.contributor.authorKaratay, Kadriye Busra
dc.contributor.authorKilcar, Ayfer Yurt
dc.contributor.authorMuftuler, Fazilet Zumrut Biber
dc.date.accessioned2024-08-25T18:47:56Z
dc.date.available2024-08-25T18:47:56Z
dc.date.issued2023
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground In recent years, there has been a significant increase in studies investigating the potential use of plant-origin products in the treatment and diagnosis of different types of cancer. Methods In this study, Estragole (EST) was isolated from basil leaves via ethanolic extraction using an 80% ethanol concentration. The isolation process was performed using the High Performance Liquid Chromatography (HPLC) method. The EST isolated from the basil plant was radiolabeled with I-131 using the iodogen method. Quality control studies of the radiolabeled EST (I-131-EST) were carried out by using Thin Layer Radio Chromatography (TLRC). Next, in vitro cell, culture studies were done to investigate the bio-affinity of plant-originated EST labeled with I-131 on human medulloblastoma (DAOY) and human glioblastoma-astrocytoma (U-87 MG) cell lines. Finally, the cytotoxicity of EST was determined, and cell uptake of I-131-EST was investigated on cancer cell lines by incorporation studies. Results As a result of these studies, it has been shown that I-131-EST has a significant uptake on the brain cells. Conclusion This result is very satisfying, and it has encouraged us to do in vivo studies for the molecule in the future.en_US
dc.identifier.doi10.2174/1874471016666230110144021
dc.identifier.endpage150en_US
dc.identifier.issn1874-4710
dc.identifier.issn1874-4729
dc.identifier.issue2en_US
dc.identifier.pmid36627786en_US
dc.identifier.scopus2-s2.0-85161263538en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage140en_US
dc.identifier.urihttps://doi.org/10.2174/1874471016666230110144021
dc.identifier.urihttps://hdl.handle.net/11454/102099
dc.identifier.volume16en_US
dc.identifier.wosWOS:001015585300006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBentham Science Publ Ltden_US
dc.relation.ispartofCurrent Radiopharmaceuticalsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240825_Gen_US
dc.subjectBasil planten_US
dc.subjectestragole (EST)en_US
dc.subjectiodine-131 (I-131)en_US
dc.subjectestragole radiolabeled with I-131 (I-131-EST)en_US
dc.subjecthuman medulloblastoma (DAOY)en_US
dc.subjecthuman glioblastoma-astrocytoma (U87-MG)en_US
dc.subjectMedicinal-Plantsen_US
dc.subjectBiodistributionen_US
dc.subjectLeavesen_US
dc.subjectI-131en_US
dc.subjectRadioiodinationen_US
dc.subjectPerspectiveen_US
dc.subjectMorphineen_US
dc.titleInvestigation of Bioactivity of Estragole Isolated from Basil Plant on Brain Cancer Cell Lines Using Nuclear Methoden_US
dc.typeArticleen_US

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