Hypertension and life-threatening bleeding in children with relapsed acute myeloblastic leukemia treated with FLT3 inhibitors [FLT3 İnhibitörleri ile tedavi edilen nüks akut miyeloblastik lösemili çocuklarda hipertansiyon ve hayatı tehdit eden kanama]

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dc.contributor.authorYılmaz Karapınar D.
dc.contributor.authorKaradaş N.
dc.contributor.authorSiviş Z.Ö.
dc.contributor.authorBalkan C.
dc.contributor.authorKavaklı K.
dc.contributor.authorAydınok Y.
dc.date.accessioned2019-10-26T21:24:06Z
dc.date.available2019-10-26T21:24:06Z
dc.date.issued2015
dc.departmentEge Üniversitesien_US
dc.description.abstractExperiences with new multikinase inhibitors are limited, especially in children. In this report we summarize our experience with 2 patients with relapsed acute myeloblastic leukemia (AML), one with FMS-like tyrosine kinase- 3-internal tandem duplication mutation and the other with a single base mutation (D835Y). Both patients received sorafenib, one for 19 days and the other for 42 days, with clofarabine-including chemotherapy. One additionally received sunitinib for a total of 20 days. Both patients developed severe pancytopenia, hypertension, life-threatening bleedings from the gastrointestinal system, and, finally, intrapulmonary hemorrhage. Although both reached severe aplasia of the bone marrow without blastic infiltration, death occurred with neutropenic sepsis. © 2015, Turkish Society of Hematology. All rights reserved.en_US
dc.identifier.doi10.4274/tjh.2014.0250en_US
dc.identifier.endpage266en_US
dc.identifier.issn1300-7777
dc.identifier.issue3en_US
dc.identifier.pmid25912283en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage263en_US
dc.identifier.urihttps://doi.org/10.4274/tjh.2014.0250
dc.identifier.urihttps://hdl.handle.net/11454/17134
dc.identifier.volume32en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTurkish Society of Hematologyen_US
dc.relation.ispartofTurkish Journal of Hematologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcute myeloblastic leukemiaen_US
dc.subjectChildrenen_US
dc.subjectD835Y mutationen_US
dc.subjectFLT3en_US
dc.subjectSorafeniben_US
dc.subjectSunitiniben_US
dc.titleHypertension and life-threatening bleeding in children with relapsed acute myeloblastic leukemia treated with FLT3 inhibitors [FLT3 İnhibitörleri ile tedavi edilen nüks akut miyeloblastik lösemili çocuklarda hipertansiyon ve hayatı tehdit eden kanama]en_US
dc.typeArticleen_US

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