Hypertension and life-threatening bleeding in children with relapsed acute myeloblastic leukemia treated with FLT3 inhibitors [FLT3 İnhibitörleri ile tedavi edilen nüks akut miyeloblastik lösemili çocuklarda hipertansiyon ve hayatı tehdit eden kanama]
Küçük Resim Yok
Tarih
2015
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Turkish Society of Hematology
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Experiences with new multikinase inhibitors are limited, especially in children. In this report we summarize our experience with 2 patients with relapsed acute myeloblastic leukemia (AML), one with FMS-like tyrosine kinase- 3-internal tandem duplication mutation and the other with a single base mutation (D835Y). Both patients received sorafenib, one for 19 days and the other for 42 days, with clofarabine-including chemotherapy. One additionally received sunitinib for a total of 20 days. Both patients developed severe pancytopenia, hypertension, life-threatening bleedings from the gastrointestinal system, and, finally, intrapulmonary hemorrhage. Although both reached severe aplasia of the bone marrow without blastic infiltration, death occurred with neutropenic sepsis. © 2015, Turkish Society of Hematology. All rights reserved.
Açıklama
Anahtar Kelimeler
Acute myeloblastic leukemia, Children, D835Y mutation, FLT3, Sorafenib, Sunitinib
Kaynak
Turkish Journal of Hematology
WoS Q Değeri
Scopus Q Değeri
Q3
Cilt
32
Sayı
3
