Beneficial effects of agomelatine in experimental model of sepsis-related acute kidney injury [Sepsis nedenli akut böbrek hasarında agomelatinin etkilerinin değerlendirilmesi]

Basit Öğe Kaydı
dc.contributor.authorBaşol N.
dc.contributor.authorErbaş O.
dc.contributor.authorÇavuşoğlu T.
dc.contributor.authorMeral A.
dc.contributor.authorAteş U.
dc.date.accessioned2019-10-27T08:20:58Z
dc.date.available2019-10-27T08:20:58Z
dc.date.issued2016
dc.departmentEge Üniversitesien_US
dc.description.abstractBACKGROUND: Sepsis-related acute kidney injury (AKI) is a serious complication of sepsis. Problems persist regarding early diagnosis and treatment of AKI. The aim of the present study was to evaluate the efficacy of agomelatine, which is primarily known for its positive effects on depressive and anxiety disorders in sepsis-related AKI. METHODS: Sepsis model was created with cecal ligation puncture (CLP). Rats were separated into 4 groups of 8 each: the control group, the sham-operated group, the CLP+saline group, and the CLP+agomelatine group. Agomelatine was administered intraperitoneally in doses of 20 mg/kg. RESULTS: In the agomelatine group, reductions were observed in levels of tumor necrosis factor ? (TNF-?), malondialdehyde (MDA), blood urea nitrogen (BUN), and creatinine, as well as in histological kidney scores, compared to the non-treated group. In addition, it was demonstrated that agomelatine treatment had positive effect on sepsis-induced morphological damage to renal and tubular tissues. CONCLUSION: Agomelatine showed strong efficacy in sepsis-related AKI, demonstrated with histological and biochemical results in an experimental model. It is believed that antioxidant and pro-inflammatory effects of agomelatine are responsible for the improvement in kidneys. © 2016 TJTES.en_US
dc.identifier.doi10.5505/tjtes.2015.29499en_US
dc.identifier.endpage126en_US
dc.identifier.issn1306-696X
dc.identifier.issue2en_US
dc.identifier.pmid27193977en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage121en_US
dc.identifier.urihttps://doi.org/10.5505/tjtes.2015.29499
dc.identifier.urihttps://hdl.handle.net/11454/25870
dc.identifier.volume22en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTurkish Association of Trauma and Emergency Surgeryen_US
dc.relation.ispartofUlusal Travma ve Acil Cerrahi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcute kidney injuryen_US
dc.subjectAgomelatineen_US
dc.subjectCecal ligation punctureen_US
dc.subjectSepsisen_US
dc.titleBeneficial effects of agomelatine in experimental model of sepsis-related acute kidney injury [Sepsis nedenli akut böbrek hasarında agomelatinin etkilerinin değerlendirilmesi]en_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu