Beneficial effects of agomelatine in experimental model of sepsis-related acute kidney injury [Sepsis nedenli akut böbrek hasarında agomelatinin etkilerinin değerlendirilmesi]
Küçük Resim Yok
Tarih
2016
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Turkish Association of Trauma and Emergency Surgery
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
BACKGROUND: Sepsis-related acute kidney injury (AKI) is a serious complication of sepsis. Problems persist regarding early diagnosis and treatment of AKI. The aim of the present study was to evaluate the efficacy of agomelatine, which is primarily known for its positive effects on depressive and anxiety disorders in sepsis-related AKI. METHODS: Sepsis model was created with cecal ligation puncture (CLP). Rats were separated into 4 groups of 8 each: the control group, the sham-operated group, the CLP+saline group, and the CLP+agomelatine group. Agomelatine was administered intraperitoneally in doses of 20 mg/kg. RESULTS: In the agomelatine group, reductions were observed in levels of tumor necrosis factor ? (TNF-?), malondialdehyde (MDA), blood urea nitrogen (BUN), and creatinine, as well as in histological kidney scores, compared to the non-treated group. In addition, it was demonstrated that agomelatine treatment had positive effect on sepsis-induced morphological damage to renal and tubular tissues. CONCLUSION: Agomelatine showed strong efficacy in sepsis-related AKI, demonstrated with histological and biochemical results in an experimental model. It is believed that antioxidant and pro-inflammatory effects of agomelatine are responsible for the improvement in kidneys. © 2016 TJTES.
Açıklama
Anahtar Kelimeler
Acute kidney injury, Agomelatine, Cecal ligation puncture, Sepsis
Kaynak
Ulusal Travma ve Acil Cerrahi Dergisi
WoS Q Değeri
Scopus Q Değeri
Q2
Cilt
22
Sayı
2
