Murine and math models for the level of stable mixed chimerism to cure ß-thalassemia by nonmyeloablative bone marrow transplantation

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dc.contributor.authorRoberts C.
dc.contributor.authorKean L.
dc.contributor.authorArcher D.
dc.contributor.authorBalkan C.
dc.contributor.authorHsu L.L.
dc.date.accessioned2019-10-27T00:12:08Z
dc.date.available2019-10-27T00:12:08Z
dc.date.issued2005
dc.departmentEge Üniversitesien_US
dc.description.abstractStable mixed chimeric stem cell transplantation in hemoglobinopathies exploits shorter erythroid survival in hemolytic anemias, providing normal donor red blood cells with a competitive survival advantage. This study examined the level of stable mixed chimerism necessary for complete hematological cure of the thalassemic phenotype, using a nonmyeloablative busulfan chemotherapeutic preparation. Thalassemic mice transplanted from congenic wild-type donors developed partial mixed chimerism. Hematologic cure required >80% donor red blood cells and only >13% donor white blood cells. Murine and human transplant results were compared with a math model for survival advantage of donor peripheral blood cells produced by steady-state chimeric marrow. © 2005 New York Academy of Sciences.en_US
dc.identifier.doi10.1196/annals.1345.061en_US
dc.identifier.endpage428en_US
dc.identifier.issn0077-8923
dc.identifier.pmid16339691en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage423en_US
dc.identifier.urihttps://doi.org/10.1196/annals.1345.061
dc.identifier.urihttps://hdl.handle.net/11454/22288
dc.identifier.volume1054en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherNew York Academy of Sciencesen_US
dc.relation.ispartofAnnals of the New York Academy of Sciencesen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBone marrow transplanten_US
dc.subjectChimerismen_US
dc.subjectHemolytic anemiaen_US
dc.subjectMathematical modelen_US
dc.subjectMoose modelen_US
dc.subjectNonmyeloablative transplanten_US
dc.subjectSickle cellen_US
dc.subjectThalassemiaen_US
dc.titleMurine and math models for the level of stable mixed chimerism to cure ß-thalassemia by nonmyeloablative bone marrow transplantationen_US
dc.typeConference Objecten_US

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