Murine and math models for the level of stable mixed chimerism to cure ß-thalassemia by nonmyeloablative bone marrow transplantation
Küçük Resim Yok
Tarih
2005
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
New York Academy of Sciences
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Stable mixed chimeric stem cell transplantation in hemoglobinopathies exploits shorter erythroid survival in hemolytic anemias, providing normal donor red blood cells with a competitive survival advantage. This study examined the level of stable mixed chimerism necessary for complete hematological cure of the thalassemic phenotype, using a nonmyeloablative busulfan chemotherapeutic preparation. Thalassemic mice transplanted from congenic wild-type donors developed partial mixed chimerism. Hematologic cure required >80% donor red blood cells and only >13% donor white blood cells. Murine and human transplant results were compared with a math model for survival advantage of donor peripheral blood cells produced by steady-state chimeric marrow. © 2005 New York Academy of Sciences.
Açıklama
Anahtar Kelimeler
Bone marrow transplant, Chimerism, Hemolytic anemia, Mathematical model, Moose model, Nonmyeloablative transplant, Sickle cell, Thalassemia
Kaynak
Annals of the New York Academy of Sciences
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
1054
