The Role of Mitochondrial Biogenesis in Ischemic Stroke
Küçük Resim Yok
Tarih
2023
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
IMR Press Limited
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Ischaemic stroke is a sudden neurological disorder caused by localised cerebral ischaemia and persistent cerebral infarction. Occlusion of large arteries due to atherothrombosis, cerebral embolism (i.e., embolic infarction), no thrombotic occlusion in small, deep cerebral arteries (i.e., lacunar infarction), and stenosis of proximal arteries due to hypotension leading to decreased cerebral blood flow in arterial supply zones are the most common causes of ischemic stroke (i.e., hemodynamic stroke). It is now known that organelles play an important role in various signaling events and cellular functions. The molecular mechanisms of mitochondria are involved in cerebral ischemia by generating and scavenging reactive oxygen species, apoptosis, biogenesis, mitochondrial dynamics, and inflammation are all examples of electron transport chain dysfunction. More knowledge about the involvement of mitochondria in ischemia-induced neuronal death and neuronal protection will contribute to the development of better treatment programs for stroke syndromes such as ischemic stroke. © 2023 The Author(s). Published by IMR Press.
Açıklama
Anahtar Kelimeler
electron transport chain, ischemic stroke, mitochondrial biogenesis, neuronal death, reactive oxygen metabolite, apoptosis, brain mitochondrion, cell function, cell structure, human, ischemic stroke, mitochondrial biogenesis, mitochondrial dynamics, mitochondrial respiration, nerve cell, nerve degeneration, nervous system inflammation, nonhuman, oxidative stress, pathophysiology, respiratory chain, Review
Kaynak
Journal of Integrative Neuroscience
WoS Q Değeri
Scopus Q Değeri
Q3
Cilt
22
Sayı
4
