A Case of Plasmodium vivax Complicated with Reactive Hemophagocytic Syndrome

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dc.authorscopusid57990278000
dc.authorscopusid57990295500
dc.authorscopusid57553989200
dc.authorscopusid55332209000
dc.authorscopusid57218348602
dc.authorscopusid57990262500
dc.contributor.authorHavvat, Nebil
dc.contributor.authorKurtulmus, Ilkce Akgun
dc.contributor.authorGunes, Ajda
dc.contributor.authorZorbozan, Orcun
dc.contributor.authorKilincer Bozgul, Sukriye Miray
dc.contributor.authorBozkurt, Devrim
dc.date.accessioned2023-01-12T20:19:04Z
dc.date.available2023-01-12T20:19:04Z
dc.date.issued2022
dc.departmentN/A/Departmenten_US
dc.description.abstractPlasmodium vivax is the most common malaria agent in the world, transmitted by vectoring of anopheles mosquitoes. In the clinical course of the disease, non-specific signs of infection (fever, myalgia, joint pain, nausea, vomiting, etc.) can be seen. Hemophagocytic lymphohistiocytosis; also known as hemophagocytic syndrome, is a rapid-onset and life-threatening clinical condition that develops as a result of uncontrolled immune activation and hypercytokinemia. In this case report, a case who developed hemophagocytic syndrome while under treatment for P.vivax infection was presented. A 37-year-old male patient applied to us with the complaints of high fever, chills-shivering and weakness, started on his return from Sudan. Upon admission, the fever was 40 degrees C, the pulse was rhythmic and 115/minute, the respiratory rate was 24/minute, and the blood pressure was 80/49 mmHg, and he was followed up in the intensive care unit due to the signs of systemic inflammatory response syndrome. During the investigation of the etiology of fever, it was learned that he did not receive prophylaxis for malaria during his stay in Sudan. Thin and thick blood smears were examined. P.vivax infection was detected in the patient and the treatment was initiated, a bone marrow aspiration biopsy was performed with the prediagnosis of hemophagocytic syndrome with persistent fever, deepening of thrombocytopenia, findings of hyperferritinemia, hypertriglyceridemia, hepatosplenomegaly, and myeloid serial hemophagocytosis in the 48th hour of the treatment. In addition to antimalarial therapy, clinical and laboratory response was obtained with polyclonal intravenous immunoglobulin (IVIG) therapy.en_US
dc.identifier.doi10.5578/mb.20229612
dc.identifier.endpage754en_US
dc.identifier.issn0374-9096
dc.identifier.issue4en_US
dc.identifier.pmid36458720en_US
dc.identifier.scopus2-s2.0-85143184790en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage749en_US
dc.identifier.trdizinid1135585en_US
dc.identifier.urihttps://doi.org/10.5578/mb.20229612
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1135585
dc.identifier.urihttps://hdl.handle.net/11454/79022
dc.identifier.volume56en_US
dc.identifier.wosWOS:000878101400015en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAnkara Microbiology Socen_US
dc.relation.ispartofMikrobiyoloji Bultenien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHemophagocytosisen_US
dc.subjecthemophagocytic lymphohistiocytosisen_US
dc.subjectPlasmodium vivaxen_US
dc.subjectmalariaen_US
dc.subjectEpidemiologyen_US
dc.subjectGuidelinesen_US
dc.titleA Case of Plasmodium vivax Complicated with Reactive Hemophagocytic Syndromeen_US
dc.title.alternativeReaktif Hemofagositik Sendrom ile Komplike Olan Plasmodium vivax Olgusuen_US
dc.typeArticleen_US

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