Collagen/physiologically clotted fibrin-based nanobioscaffold supported with silver nanoparticles: A novel approach

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dc.authoridKavukcu, Serdar Batikan/0000-0002-1168-5012
dc.authorscopusid57221128330
dc.authorscopusid57207820119
dc.authorscopusid57221436939
dc.authorscopusid57857767400
dc.authorscopusid57857767500
dc.authorwosidt, l/GZN-1073-2022
dc.authorwosidT, Lakshmi/AAL-4695-2020
dc.contributor.authorSenthil, Rethinam
dc.contributor.authorKavukcu, Serdar Batikan
dc.contributor.authorLakshmi, Thangavelu
dc.contributor.authorGulsah, Turkmen
dc.contributor.authorCandas, Adiguzel Zengin Arife
dc.date.accessioned2023-01-12T20:03:39Z
dc.date.available2023-01-12T20:03:39Z
dc.date.issued2022
dc.departmentN/A/Departmenten_US
dc.description.abstractPurpose: In this work, a blend of collagen, physiologically clotted fibrin (PCF), and silver nanoparticles (AgNPs) is used to develop a nanobioscaffold (NBS), for their possible application in wound dressing materials. Methods: The prepared NBS were evaluated using physicochemical, mechanical, and antibacterial properties. The NBS cell viability was demonstrated in a biocompatibility study using the human keratinocyte cell line (HaCaT). Results: The results demonstrated that the NBS had excellent tensile strength (22.15 +/- 0.05 MPa), elongation at break (13.32 +/- 0.09%), and water absorption (97.51 +/- 0.08). The in-vitro study demonstrated its biocompatible nature. NBS exhibited significant antibacterial activity against the Gram-negative and Gram-positive bacteria. Conclusion: The NBS with required mechanical strength, antibacterial activity, and biocompatibility may be tested as a wound material in rats after getting the necessary approval.en_US
dc.description.sponsorshipTUBITAK [118C350]en_US
dc.description.sponsorshipSenthil Rethinam acknowledges the funding support granted by the 2232-International Fellowship for Outstanding Researcher Program of TUBITAK (Project No: 118C350).en_US
dc.identifier.doi10.1177/03913988221119529
dc.identifier.issn0391-3988
dc.identifier.issn1724-6040
dc.identifier.pmid35993241en_US
dc.identifier.scopus2-s2.0-85136585841en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1177/03913988221119529
dc.identifier.urihttps://hdl.handle.net/11454/77715
dc.identifier.wosWOS:000842688000001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofInternational Journal of Artificial Organsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNanobioscaffoldsen_US
dc.subjectbiocompatibilityen_US
dc.subjectantibacterialen_US
dc.subjectcollagenen_US
dc.subjectfibrinen_US
dc.subjectWound Dressing Materialen_US
dc.subjectGraphene Oxideen_US
dc.subjectCompositesen_US
dc.subjectCollagenen_US
dc.subjectGelatinen_US
dc.titleCollagen/physiologically clotted fibrin-based nanobioscaffold supported with silver nanoparticles: A novel approachen_US
dc.typeArticleen_US

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