Collagen/physiologically clotted fibrin-based nanobioscaffold supported with silver nanoparticles: A novel approach
Küçük Resim Yok
Tarih
2022
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Sage Publications Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Purpose: In this work, a blend of collagen, physiologically clotted fibrin (PCF), and silver nanoparticles (AgNPs) is used to develop a nanobioscaffold (NBS), for their possible application in wound dressing materials. Methods: The prepared NBS were evaluated using physicochemical, mechanical, and antibacterial properties. The NBS cell viability was demonstrated in a biocompatibility study using the human keratinocyte cell line (HaCaT). Results: The results demonstrated that the NBS had excellent tensile strength (22.15 +/- 0.05 MPa), elongation at break (13.32 +/- 0.09%), and water absorption (97.51 +/- 0.08). The in-vitro study demonstrated its biocompatible nature. NBS exhibited significant antibacterial activity against the Gram-negative and Gram-positive bacteria. Conclusion: The NBS with required mechanical strength, antibacterial activity, and biocompatibility may be tested as a wound material in rats after getting the necessary approval.
Açıklama
Anahtar Kelimeler
Nanobioscaffolds, biocompatibility, antibacterial, collagen, fibrin, Wound Dressing Material, Graphene Oxide, Composites, Collagen, Gelatin
Kaynak
International Journal of Artificial Organs
WoS Q Değeri
Q3
Scopus Q Değeri
Q3
