The effect of phenyramidol on neural development in early chicken embryo model

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dc.contributor.authorOzgural O.
dc.contributor.authorBahadir B.
dc.contributor.authorDogan I.
dc.contributor.authorEroglu U.
dc.contributor.authorAktan S.
dc.contributor.authorKar I.
dc.contributor.authorUnlu A.
dc.date.accessioned2021-05-03T20:51:55Z
dc.date.available2021-05-03T20:51:55Z
dc.date.issued2019
dc.description.abstractAIM: To investigate the effects of Phenyramidol (Phe) on neural development in an early chicken embryo model. MATERIAL and METHODS: Sixty fertile non-pathogenic Super Nick eggs were incubated for 24 hours (h) and divided into four groups of 15 eggs each. Phe was administrated through the sub-blastoderm, and the eggs were incubated for another 24 h. All eggs were opened after 48 h of incubation, and the embryos were evaluated morphologically and histopathologically. RESULTS: In Group 1 (control group), none exhibited neural tube defects (NTDs) (0%), 1 (6.6%) was undeveloped; in Group 2 (low dosages), 1 did not develop (6.6%); in Group 3 (normal dosages), 2 (13.4%) had NTDs, 1 (6.6%) was undeveloped; in Group 4 (high dosages), 5 (33.3%) had NTDs, 2 (13.3%) were undeveloped. CONCLUSION: In light of the results, it was determined that the use of increasing doses of Phe led to defects in midline closure in early chicken embryos. This is the first report in the literature on Phe used in an early chicken embryo model. © 2019, Turkish Neurosurgical Society.en_US
dc.description.sponsorshipPreparation for publication of this article is partly supported by Turkish Neurosurgical Society.en_US
dc.identifier.doi10.5137/1019-5149.JTN.26158-19.1en_US
dc.identifier.endpage855en_US
dc.identifier.issn1019-5149
dc.identifier.issue6en_US
dc.identifier.pmid31192442en_US
dc.identifier.scopus2-s2.0-85075805534en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage851en_US
dc.identifier.urihttps://doi.org/10.5137/1019-5149.JTN.26158-19.1
dc.identifier.urihttps://hdl.handle.net/11454/70966
dc.identifier.volume29en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTurkish Neurosurgical Societyen_US
dc.relation.ispartofTurkish Neurosurgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectChicken embryoen_US
dc.subjectGrowth retardationen_US
dc.subjectMyorelaxant drugen_US
dc.subjectNeural tube defecten_US
dc.subjectPhenyramidolen_US
dc.subjectUndeveloped embryoen_US
dc.titleThe effect of phenyramidol on neural development in early chicken embryo modelen_US
dc.typeArticleen_US

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