The effect of phenyramidol on neural development in early chicken embryo model
Küçük Resim Yok
Tarih
2019
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Turkish Neurosurgical Society
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
AIM: To investigate the effects of Phenyramidol (Phe) on neural development in an early chicken embryo model. MATERIAL and METHODS: Sixty fertile non-pathogenic Super Nick eggs were incubated for 24 hours (h) and divided into four groups of 15 eggs each. Phe was administrated through the sub-blastoderm, and the eggs were incubated for another 24 h. All eggs were opened after 48 h of incubation, and the embryos were evaluated morphologically and histopathologically. RESULTS: In Group 1 (control group), none exhibited neural tube defects (NTDs) (0%), 1 (6.6%) was undeveloped; in Group 2 (low dosages), 1 did not develop (6.6%); in Group 3 (normal dosages), 2 (13.4%) had NTDs, 1 (6.6%) was undeveloped; in Group 4 (high dosages), 5 (33.3%) had NTDs, 2 (13.3%) were undeveloped. CONCLUSION: In light of the results, it was determined that the use of increasing doses of Phe led to defects in midline closure in early chicken embryos. This is the first report in the literature on Phe used in an early chicken embryo model. © 2019, Turkish Neurosurgical Society.
Açıklama
Anahtar Kelimeler
Chicken embryo, Growth retardation, Myorelaxant drug, Neural tube defect, Phenyramidol, Undeveloped embryo
Kaynak
Turkish Neurosurgery
WoS Q Değeri
Scopus Q Değeri
Q3
Cilt
29
Sayı
6
