Synthesis and anticonvulsant activity of some N-phenyl-2- phtalimidoethanesulfonamide derivatives

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dc.contributor.authorAkgul O.
dc.contributor.authorKilic F.S.
dc.contributor.authorErol K.
dc.contributor.authorPabuccuoglu V.
dc.date.accessioned2019-10-27T08:37:03Z
dc.date.available2019-10-27T08:37:03Z
dc.date.issued2007
dc.departmentEge Üniversitesien_US
dc.description.abstractIn this study, inspired by the structures of the taltrimide, 2-phthalimidoethanesulphonamide, and the anilide pharmacophore known to be synthetically produced anticonvulsant compounds, fifteen N-phenyl-2- phtalimidoethanesulfonamide derivatives bearing substituents with diverse electronic and hydrophobic features on N-phenyl ring were synthesized. The structural confirmation of the title compounds was achieved by interpretation of spectral and analytical data. The anticonvulsant activity of the title compounds was determined against maximal electroshock seizure in mice at a dose level of 100 mg/kg. The preliminary screening results indicated that the exchange of the N-isopropyl moiety for an N-phenyl ring in the taltrimide molecule abolished the anticonvulsant activity. However, introducing certain substituents, such as nitro, methyl, and chloro, into the N-phenyl ring lead to more active compounds in comparison to the unsubstituted derivatives. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.en_US
dc.identifier.doi10.1002/ardp.200700166en_US
dc.identifier.endpage660en_US
dc.identifier.issn0365-6233
dc.identifier.issue12en_US
dc.identifier.pmid18038376en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage656en_US
dc.identifier.urihttps://doi.org/10.1002/ardp.200700166
dc.identifier.urihttps://hdl.handle.net/11454/27475
dc.identifier.volume340en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofArchiv der Pharmazieen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnticonvulsanten_US
dc.subjectMESen_US
dc.subjectN-Phenyl-2-phtalimidoethanesulfonamideen_US
dc.subjectTaltrimideen_US
dc.subjectTaurineen_US
dc.titleSynthesis and anticonvulsant activity of some N-phenyl-2- phtalimidoethanesulfonamide derivativesen_US
dc.typeArticleen_US

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