Synthesis and anticonvulsant activity of some N-phenyl-2- phtalimidoethanesulfonamide derivatives
Küçük Resim Yok
Tarih
2007
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
In this study, inspired by the structures of the taltrimide, 2-phthalimidoethanesulphonamide, and the anilide pharmacophore known to be synthetically produced anticonvulsant compounds, fifteen N-phenyl-2- phtalimidoethanesulfonamide derivatives bearing substituents with diverse electronic and hydrophobic features on N-phenyl ring were synthesized. The structural confirmation of the title compounds was achieved by interpretation of spectral and analytical data. The anticonvulsant activity of the title compounds was determined against maximal electroshock seizure in mice at a dose level of 100 mg/kg. The preliminary screening results indicated that the exchange of the N-isopropyl moiety for an N-phenyl ring in the taltrimide molecule abolished the anticonvulsant activity. However, introducing certain substituents, such as nitro, methyl, and chloro, into the N-phenyl ring lead to more active compounds in comparison to the unsubstituted derivatives. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.
Açıklama
Anahtar Kelimeler
Anticonvulsant, MES, N-Phenyl-2-phtalimidoethanesulfonamide, Taltrimide, Taurine
Kaynak
Archiv der Pharmazie
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
340
Sayı
12
