A fatal case of tuberculous meningitis in a child with juvenile idiopathic arthritis: a diagnostic challenge

dc.contributor.authorBal, Zumrut Sahbudak
dc.contributor.authorYazici, Pinar
dc.contributor.authorSen, Semra
dc.contributor.authorEraslan, Cenk
dc.contributor.authorCavusoglu, Cengiz
dc.contributor.authorKarapinar, Bulent
dc.contributor.authorVardar, Fadil
dc.date.accessioned2019-10-27T11:05:41Z
dc.date.available2019-10-27T11:05:41Z
dc.date.issued2017
dc.departmentEge Üniversitesien_US
dc.description.abstractThe prognosis of tuberculous meningitis, a rare form of extrapulmonary tuberculosis, depends on the stage of treatment initiation. We report a fatal case of tuberculous meningitis. The patient had received successive tumor necrosis factor (TNF) antagonists and abatacept to treat juvenile idiopathic arthritis, with negative results for polymerase chain reaction and acid-fast bacilli on smear, had normal cerebrospinal fluid (CSF) adenosine deaminase and glucose levels. Six weeks post-admission, the CSF culture demonstrated Mycobacterium tuberculosis. The altered immunological responses caused by anti-TNF treatment made the diagnosis challenging. Clinicians should bear this in mind and, if suspected, treatment should be initiated immediately.en_US
dc.identifier.doi10.1590/0037-8682-0410-2016en_US
dc.identifier.endpage711en_US
dc.identifier.issn0037-8682
dc.identifier.issue5en_US
dc.identifier.pmid29160524en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage709en_US
dc.identifier.urihttps://doi.org/10.1590/0037-8682-0410-2016
dc.identifier.urihttps://hdl.handle.net/11454/31716
dc.identifier.volume50en_US
dc.identifier.wosWOS:000414732300023en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSoc Brasileira Medicina Tropicalen_US
dc.relation.ispartofRevista Da Sociedade Brasileira De Medicina Tropicalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectTuberculosisen_US
dc.subjectTumor necrosis factor antagonisten_US
dc.subjectJuvenile idiopathic arthritisen_US
dc.titleA fatal case of tuberculous meningitis in a child with juvenile idiopathic arthritis: a diagnostic challengeen_US
dc.typeArticleen_US

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