A fatal case of tuberculous meningitis in a child with juvenile idiopathic arthritis: a diagnostic challenge
Küçük Resim Yok
Tarih
2017
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Soc Brasileira Medicina Tropical
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
The prognosis of tuberculous meningitis, a rare form of extrapulmonary tuberculosis, depends on the stage of treatment initiation. We report a fatal case of tuberculous meningitis. The patient had received successive tumor necrosis factor (TNF) antagonists and abatacept to treat juvenile idiopathic arthritis, with negative results for polymerase chain reaction and acid-fast bacilli on smear, had normal cerebrospinal fluid (CSF) adenosine deaminase and glucose levels. Six weeks post-admission, the CSF culture demonstrated Mycobacterium tuberculosis. The altered immunological responses caused by anti-TNF treatment made the diagnosis challenging. Clinicians should bear this in mind and, if suspected, treatment should be initiated immediately.
Açıklama
Anahtar Kelimeler
Tuberculosis, Tumor necrosis factor antagonist, Juvenile idiopathic arthritis
Kaynak
Revista Da Sociedade Brasileira De Medicina Tropical
WoS Q Değeri
Q3
Scopus Q Değeri
Q3
Cilt
50
Sayı
5
