Basal and pentagastrin-stimulated calcitonin cut-off values in diagnosis of preoperative medullary thyroid cancer

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dc.authoridKartal Baykan, Emine/0000-0001-6813-883X
dc.authorscopusid55753879900
dc.authorscopusid26022436600
dc.authorwosidkartal baykan, emine/AAE-4852-2022
dc.contributor.authorKartal Baykan, Emine
dc.contributor.authorErdogan, Mehmet
dc.date.accessioned2023-01-12T20:16:05Z
dc.date.available2023-01-12T20:16:05Z
dc.date.issued2021
dc.departmentN/A/Departmenten_US
dc.description.abstractBackground/aim: Medullary thyroid cancer (MTC) originates from parafollicular cells (C cell) and produces calcitonin (CT). Basal serum CT was used in the diagnosis and treatment of MTC. If basal CT level is 100 pg/mL or higher, it is likely to have MTC, but if basal CT level is below 10 pg/mL, the probability of developing thyroid disease is low. In cases with basal CT level between 10?100 pg/mL, pentagastrin-stimulated (PS) CT level is studied to evaluate MTC and C cell hyperplasia (CHH). This study aimed to determine cut-off value for basal and PS peak CT level for diagnosis of MTC. Materials and methods: We retrospectively reviewed files of patients presented to endocrine outpatient clinic of Ege University, Medicine School, between 2010 and 2019; 176 patients with basal CT level of 10?100 pg/mL and patients with PS test were included to the study. Results: The receiver operating characteristic curve (ROC) analysis was used to determine cut-off value for basal CT that can discriminate cases with MTC and those with nodular goiter. Cut-off value for basal CT was calculated as 46.5 pg/mL (specificity; 100 %, sensitivity; 74 %). In the ROC analysis for peak PS CT, cut-off value was calculated as 285 pg/mL (specificity:100 %; sensitivity:82 %). When peak CT level was > 290 pg/mL in PS test, both specificity and sensitivity for MTC were determined as 100 %. The PS peak CT level > 285 pg/ mL was significant for MTC diagnosis while range of 117?274 pg/mL was significant for CHH. Conclusion: In this study, cut-off value was calculated as 46.5 pg/mL for basal CT, whereas 285 pg/mL for PS peak CT in the diagnosis of preoperative MTC.en_US
dc.identifier.doi10.3906/sag-2003-182
dc.identifier.endpage656en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue2en_US
dc.identifier.pmid33128357en_US
dc.identifier.scopus2-s2.0-85105443544en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage650en_US
dc.identifier.trdizinid483911en_US
dc.identifier.urihttps://doi.org/10.3906/sag-2003-182
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/483911
dc.identifier.urihttps://hdl.handle.net/11454/78644
dc.identifier.volume51en_US
dc.identifier.wosWOS:000646281600034en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTubitak Scientific & Technical Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMedullary thyroid canceren_US
dc.subjectC cell hyperplasiaen_US
dc.subjectcalcitoninen_US
dc.subjectpentagastrinen_US
dc.subjectcut-offen_US
dc.subjectC-Cell Hyperplasiaen_US
dc.subjectSerum Calcitoninen_US
dc.subjectRoutine Measurementen_US
dc.subjectDifferential-Diagnosisen_US
dc.subjectRet Protooncogeneen_US
dc.subjectPlasma Calcitoninen_US
dc.subjectPredictive-Valueen_US
dc.subjectFollow-Upen_US
dc.subjectCarcinomaen_US
dc.subjectCalciumen_US
dc.titleBasal and pentagastrin-stimulated calcitonin cut-off values in diagnosis of preoperative medullary thyroid canceren_US
dc.typeArticleen_US

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