Low pertussis antibody levels in maternal and umbilical cord blood samples in Turkey

Basit Öğe Kaydı
dc.contributor.authorTurkoglu, Ebru
dc.contributor.authorSonmez, Cemile
dc.contributor.authorOzer, Esra
dc.contributor.authorCoplu, Nilay
dc.contributor.authorKurugol, Zafer
dc.date.accessioned2019-10-27T11:25:10Z
dc.date.available2019-10-27T11:25:10Z
dc.date.issued2016
dc.departmentEge Üniversitesien_US
dc.description.abstractPertussis continues to cause significant mortality and morbidity in many countries despite high vaccine coverage, especially among young infants. The aim of the study was to determine pertussis antibody levels in paired maternal and cord blood samples, to evaluate the placental transfer of these antibodies, and to assess whether newborn infants have adequate antibody levels against pertussis. Antibody titers to pertussis toxin (anti-PT) and filamentous hemagglutinin (anti-FHA) were measured by in-house enzyme linked immunosorbent assay (ELISA) in 251 paired maternal delivery and cord blood samples. Geometric mean concentrations (GMCs) of pertussis antibodies and cord: maternal GMC ratios were calculated. GMCs of maternal anti-PT and anti-FHA antibodies at delivery were 4.12 and 9.89 EU/ml, respectively. Cord GMCs were 133% and 131% of maternal delivery values for PT and FHA, respectively; demonstrating effective placental transfer. However, cord pertussis antibodies were at a low concentration; 5.49 EU/ml for PT and 12.73 EU/ml for FHA. Only 34.6% of infants had protective anti-PT levels (>= 10 EU/ml) at birth. Anti-pertussis antibody concentrations were extremely low in pregnant women in Turkey where childhood pertussis vaccination coverage has been high for a long time. Despite effective placental antibody transfer, umbilical cord pertussis antibody concentrations are similarly low. A majority of young infants are vulnerable to pertussis infection until the onset of primary vaccinations. These data support the need for pertussis vaccination during pregnancy to prevent infant infection in Turkey.en_US
dc.identifier.doi10.24953/turkjped.2016.06.001
dc.identifier.endpage578en_US
dc.identifier.issn0041-4301
dc.identifier.issue6en_US
dc.identifier.pmid29090869en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage573en_US
dc.identifier.urihttps://doi.org/10.24953/turkjped.2016.06.001
dc.identifier.urihttps://hdl.handle.net/11454/33365
dc.identifier.volume58en_US
dc.identifier.wosWOS:000415748800001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTurkish J Pediatricsen_US
dc.relation.ispartofTurkish Journal of Pediatricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectcord blooden_US
dc.subjectpertussisen_US
dc.subjectpertussis antibodiesen_US
dc.subjectpregnant womenen_US
dc.subjectseroprevalanceen_US
dc.titleLow pertussis antibody levels in maternal and umbilical cord blood samples in Turkeyen_US
dc.typeArticleen_US

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