Biodistribution of radiolabeled alpha-amanitin in mice: An Investigation

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dc.authoridBARIŞ, Elif/0000-0001-6838-7932
dc.authoridIchedef, Cigdem/0000-0002-1586-9521
dc.authoridDurkan, Kubra/0000-0002-0783-8557
dc.contributor.authorDurkan, Kubra
dc.contributor.authorIchedef, Cigdem
dc.contributor.authorBaris, Elif
dc.contributor.authorArici, M. Aylin
dc.date.accessioned2024-08-31T07:46:56Z
dc.date.available2024-08-31T07:46:56Z
dc.date.issued2024
dc.departmentEge Üniversitesien_US
dc.description.abstractMushroom poisonings caused by Amanita phalloides are the leading cause of mushroom -related deaths worldwide. Alpha-Amanitin (alpha-AMA), a toxic substance present in these mushrooms, is responsible for the resulting hepatotoxicity and nephrotoxicity. The objective of our study was to determine the distribution of alpha-AMA in Balb/c mice by labeling with Iodine -131. Mice were injected with a toxic dose (1.4 mg/kg) of alpha-AMA labeled with Iodine -131. The mice were sacrificed at the 1st, 2nd, 4th, 8th, 24th, and 48th hours under anesthesia. The organs of the mice were removed, and their biodistribution was assessed in all experiments. The percent injected dose per gram (ID/g %) value for kidney, liver, lung, and heart tissues at 1st hour were 1.59 +/- 0.07, 1.25 +/- 0.33, 3.67 +/- 0.80 and 1.07 +/- 0.01 respectively. This study provides insights into the potential long-term effects of alpha-AMA accumulation in specific organs. Additionally, this study has generated essential data that can be used to demonstrate the impact of antidotes on the biological distribution of alpha-AMA in future toxicity models.en_US
dc.description.sponsorshipEge University Scientific Research BornovaIzmir, Turkey; [23987]en_US
dc.description.sponsorshipPresent study was financially supported by the Ege University Scientific Research Project numbered 23987 (BornovaIzmir, Turkey) .en_US
dc.identifier.doi10.1016/j.toxicon.2024.107661
dc.identifier.issn0041-0101
dc.identifier.issn1879-3150
dc.identifier.pmid38408526en_US
dc.identifier.scopus2-s2.0-85186750255en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1016/j.toxicon.2024.107661
dc.identifier.urihttps://hdl.handle.net/11454/104250
dc.identifier.volume241en_US
dc.identifier.wosWOS:001218587800001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofToxiconen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240831_Uen_US
dc.subjectAlpha-Amanitinen_US
dc.subjectAmanita Phalloidesen_US
dc.subjectToxicityen_US
dc.subjectIn Vivo Biodistributionen_US
dc.subjectI-131en_US
dc.titleBiodistribution of radiolabeled alpha-amanitin in mice: An Investigationen_US
dc.typeArticleen_US

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