RT-PCR-based cytochrome P450 expression profile of oral tissue samples

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dc.contributor.authorSarikaya, D.
dc.contributor.authorChiba, I.
dc.contributor.authorBilgen, C.
dc.contributor.authorKamatakil, T., I
dc.contributor.authorTopcu, Z.
dc.date.accessioned2019-10-27T20:01:28Z
dc.date.available2019-10-27T20:01:28Z
dc.date.issued2007
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective: To analyse the expression of individual forms of cytochrome P450 (CYP) at the mRNA level in five homogenized oral buccal tissue samples from four individuals with or without oral malignancy. Method: Individual forms of CYPs were studied by reverse transcriptase-polymerase chain reaction (RT-PCR), using specific primers for CYPs 2B6, 2C, 2D6, 2E1, 3A3/4 and 3A5, and oral CYP expressions were compared with CYP expression in liver tissue. Results: Consistent expression of CYPs 2C, 2E1 and 3A5 was observed in oral buccal tissue at mRNA level. Conclusions: These particular CYPs have possible roles in the protection of the body against orally ingested xenobiotics as well as influence the bioavailability of therapeutic compounds.en_US
dc.identifier.doi10.1111/j.1365-2710.2007.00841.xen_US
dc.identifier.endpage448en_US
dc.identifier.issn0269-4727
dc.identifier.issue5en_US
dc.identifier.pmid17875109en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage445en_US
dc.identifier.urihttps://doi.org/10.1111/j.1365-2710.2007.00841.x
dc.identifier.urihttps://hdl.handle.net/11454/41261
dc.identifier.volume32en_US
dc.identifier.wosWOS:000249450400004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBlackwell Publishingen_US
dc.relation.ispartofJournal of Clinical Pharmacy and Therapeuticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcytochrome P450en_US
dc.subjectdrug metabolizing enzymesen_US
dc.subjectoral buccal tissueen_US
dc.titleRT-PCR-based cytochrome P450 expression profile of oral tissue samplesen_US
dc.typeArticleen_US

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